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JAK2 抗体 (AA 745-955)

Cited in 3+ publications. The 小鼠 单克隆 anti-JAK2 antibody (Clone 1C1) (ABIN966429) specifically detects JAK2 in WB 和 ELISA. The antibody is reactive with 人 samples.
产品编号 ABIN966429
发货至: 中国
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Quick Overview for JAK2 抗体 (AA 745-955) (ABIN966429)

抗原

See all JAK2 抗体
JAK2 (Janus Kinase 2 (JAK2))

适用

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宿主

  • 176
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小鼠

克隆类型

  • 141
  • 42
单克隆

标记

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This JAK2 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA

克隆位点

1C1
  • 抗原表位

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    AA 745-955

    纯化方法

    Ascitic fluid

    免疫原

    Purified recombinant fragment of JAK2(745-955aa) expressed in E. Coli.

    亚型

    IgG1
  • 应用备注

    Western Bloting: 1/500 - 1/2000.
    ELISA: Propose dilution 1/10000.
    Not yet tested in other applications.
    Determining optimal working dilutions by titration test.

    限制

    仅限研究用
  • 状态

    Liquid

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C
  • Hermanns, Radtke, Haan, Schmitz-Van de Leur, Tavernier, Heinrich, Behrmann: "Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 12, pp. 6651-8, (2000) (PubMed).

    Pollack, Kotenko, He, Izotova, Barnoski, Pestka: "The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity." in: The Journal of biological chemistry, Vol. 274, Issue 44, pp. 31531-42, (1999) (PubMed).

    Mol, de Rijke, Demacker, Stalenhoef: "Plasma levels of lipid and cholesterol oxidation products and cytokines in diabetes mellitus and cigarette smoking: effects of vitamin E treatment." in: Atherosclerosis, Vol. 129, Issue 2, pp. 169-76, (1997) (PubMed).

  • 抗原

    JAK2 (Janus Kinase 2 (JAK2))

    别名

    JAK2

    背景

    This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
    Synonyms: JTK10, JAK2

    分子量

    130.6kDa

    基因ID

    3717

    途径

    JAK/STAT Signaling, RTK signaling, Interferon-gamma Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling, Unfolded Protein Response
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