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DDX58 抗体 (N-Term)

DDX58 适用: 人 IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN965986
发货至: 中国
  • 抗原 See all DDX58 抗体
    DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))
    抗原表位
    • 15
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 64
    • 41
    • 17
    • 2
    • 1
    宿主
    • 59
    • 8
    • 1
    克隆类型
    • 61
    • 7
    多克隆
    标记
    • 35
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This DDX58 antibody is un-conjugated
    应用范围
    • 61
    • 19
    • 14
    • 14
    • 14
    • 11
    • 7
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    Immunohistochemistry (IHC)
    免疫原
    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human DDX58(Probable ATP-dependent RNA helicase DDX58)(DEAD-box protein 58)
    Top Product
    Discover our top product DDX58 Primary Antibody
  • 限制
    仅限研究用
  • 储存条件
    4 °C
  • "Outbreak news. Rift Valley fever, Sudan." in: Relevé épidémiologique hebdomadaire / Section d'hygiène du Secrétariat de la Société des Nations = Weekly epidemiological record / Health Section of the Secretariat of the League of Nations, Vol. 82, Issue 46, pp. 401-2, (2007) (PubMed).

    Seth, Sun, Ea, Chen: "Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3." in: Cell, Vol. 122, Issue 5, pp. 669-82, (2005) (PubMed).

    Huang, Liu, Xu, Chen, Zhai, Shu: "SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways." in: The EMBO journal, Vol. 24, Issue 23, pp. 4018-28, (2005) (PubMed).

    Sumpter, Loo, Foy, Li, Yoneyama, Fujita, Lemon, Gale: "Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I." in: Journal of virology, Vol. 79, Issue 5, pp. 2689-99, (2005) (PubMed).

    Cui, Imaizumi, Yoshida, Borden, Satoh: "Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates the expression of interferon-gamma stimulated gene 15 in MCF-7 cells." in: Biochemistry and cell biology = Biochimie et biologie cellulaire, Vol. 82, Issue 3, pp. 401-5, (2004) (PubMed).

    Imaizumi, Aratani, Nakajima, Carlson, Matsumiya, Tanji, Ookawa, Yoshida, Tsuchida, McIntyre, Prescott, Zimmerman, Satoh: "Retinoic acid-inducible gene-I is induced in endothelial cells by LPS and regulates expression of COX-2." in: Biochemical and biophysical research communications, Vol. 292, Issue 1, pp. 274-9, (2002) (PubMed).

  • 抗原
    DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))
    别名
    DDX58 (DDX58 产品)
    别名
    RIG-I antibody, RIGI antibody, RLR-1 antibody, 6430573D20Rik antibody, C330021E21 antibody, RHIV-1 antibody, RIG-1 antibody, DExD/H-box helicase 58 antibody, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 antibody, DEXD/H-box helicase 58 antibody, DDX58 antibody, Ddx58 antibody
    背景
    DDX58(Probable ATP-dependent RNA helicase DDX58)(DEAD-box protein 58) is involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). DDX58 detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). DDX58 is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza viruses, Japanese encephalitis virus and HCV. DDX58 is maintained as a monomer in an autoinhibited state. Upon viral dsRNA binding and conformation shift, homomultimerizes and interacts with MAVS. DDX58 interacts with DHX58/LGP2, IKBKE, TBK1 and TMEM173/STING. DDX58 is present in vascular smooth cells. The repressor domain controls homomultimerization and interaction with MAVS. The helicase domain is responsible for dsRNA recognition. The 2 CARD domains are responsible for interaction with and signaling through MAVS. DDX58 is conjugated to ubiquitin-like protein ISG15 upon IFN-beta stimulation. DDX58 belongs to the helicase family and contains 2 CARD domains, 1 helicase ATP-binding domain and 1 helicase C-terminal domain.
    Synonyms: RIG-1 (Retinoic acid-inducible gene 1 protein)
    途径
    Activation of Innate immune Response, Hepatitis C
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