DDX58 抗体 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58) (AA 201-713)

Details for Product anti-DDX58 Antibody No. ABIN1169336
抗原
  • RIG-I
  • RIGI
  • RLR-1
  • 6430573D20Rik
  • C330021E21
  • RHIV-1
  • RIG-1
  • DExD/H-box helicase 58
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
  • DEXD/H-box helicase 58
  • DDX58
  • Ddx58
抗原表位
AA 201-713
17
11
4
4
3
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
适用
人, 小鼠
162
69
32
2
2
宿主
小鼠
127
27
10
3
克隆类型 (克隆位点)
单克隆 ()
标记
This DDX58 antibody is un-conjugated
11
5
5
3
3
3
3
3
3
2
2
2
2
2
应用范围
Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
116
51
43
27
26
16
13
7
4
4
3
1
选项
免疫原 Recombinant human RIG-I (aa 201-713).
克隆位点 Alme-1
亚型 IgG1
特异性 Recognizes human and mouse RIG-I.
交叉反应 人, 小鼠
纯化方法 Purified from concentrated hybridoma tissue culture supernatant.
纯度 >95 % (SDS-PAGE)
Plasmids, Primers & others Plasmids, Primers & others DDX58 products on genomics-online (e.g. as negative or positive controls)
抗原
别名 RIG-I (DDX58 Antibody 摘要)
背景 RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5'-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-I recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation.
UniProt O95786
途径 Activation of Innate immune Response, Hepatitis C
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
状态 Liquid
浓度 1 mg/mL
缓冲液 In PBS containing 10 % glycerol and 0.02 % sodium azide.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 4 °C,-20 °C
储存方法 Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.
有效期 12 months
厂商提供的图像
Western Blotting (WB) image for anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) (AA 201-713) antibody (ABIN1169336) Western blot analysis of human RIG-I in HeLa cells by using RIG-I, mAb (Alme-1) . Me...
Immunohistochemistry (IHC) image for anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) (AA 201-713) antibody (ABIN1169336) Immunohistochemical staining of endogenous human RIG-I in different human tissues (pa...
有引用在: Pythoud, Rothenberger, Martínez-Sobrido, de la Torre, Kunz: "Lymphocytic Choriomeningitis Virus Differentially Affects the Virus-Induced Type I Interferon Response and Mitochondrial Apoptosis Mediated by RIG-I/MAVS." in: Journal of virology, Vol. 89, Issue 12, pp. 6240-50, 2015 (PubMed).

Weber, Gawanbacht, Habjan, Rang, Borner, Schmidt, Veitinger, Jacob, Devignot, Kochs, García-Sastre, Weber: "Incoming RNA virus nucleocapsids containing a 5'-triphosphorylated genome activate RIG-I and antiviral signaling." in: Cell host & microbe, Vol. 13, Issue 3, pp. 336-46, 2013 (PubMed).

Gack, Nistal-Villán, Inn, García-Sastre, Jung: "Phosphorylation-mediated negative regulation of RIG-I antiviral activity." in: Journal of virology, Vol. 84, Issue 7, pp. 3220-9, 2010 (PubMed).

Rebsamen, Meylan, Curran, Tschopp: "The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases." in: Cell death and differentiation, Vol. 15, Issue 11, pp. 1804-11, 2008 (PubMed).

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