DAXX 抗体
Quick Overview for DAXX 抗体 (ABIN965974)
抗原
See all DAXX 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- Antibody are purified by protein G affinity chromatography.
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免疫原
- Purified recombinant fragment of human DAXX expressed in E. Coli.
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亚型
- IgG1
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应用备注
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Western Bloting: 1/500 - 1/2000.
Immunofluorescence: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test. -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS containing 50% glycerol
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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: "Interaction of Daxx, a Fas binding protein, with sentrin and Ubc9." in: Biochemical and biophysical research communications, Vol. 279, Issue 1, pp. 6-10, (2000) (PubMed).
: "Daxx, a novel Fas-binding protein that activates JNK and apoptosis." in: Cell, Vol. 89, Issue 7, pp. 1067-76, (1997) (PubMed).
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: "Interaction of Daxx, a Fas binding protein, with sentrin and Ubc9." in: Biochemical and biophysical research communications, Vol. 279, Issue 1, pp. 6-10, (2000) (PubMed).
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- DAXX (Death-Domain Associated Protein (DAXX))
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别名
- DAXX
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背景
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DAXX (death-domain associated protein), it is a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.
Synonyms: DAP6, EAP1, BING2 -
分子量
- 81kDa
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基因ID
- 1616
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway
抗原
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