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ADAM17 抗体 (Isoform 1)

There are 3+ publications for this product available. The 兔 多克隆 anti-ADAM17 antibody is suitable to detect ADAM17 in samples from 人. It has been validated for IHC.
产品编号 ABIN965510
发货至: 中国
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Quick Overview for ADAM17 抗体 (Isoform 1) (ABIN965510)

抗原

See all ADAM17 抗体
ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

适用

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宿主

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克隆类型

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多克隆

标记

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This ADAM17 antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC)
  • 抗原表位

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    Isoform 1

    纯化方法

    Purified by antigen-specific affinity chromatography.

    免疫原

    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ADAM17 (a disintegrin and metalloproteinase domain 17 isoform 1 preproprotein)
  • 应用备注

    ELISA, Western blotting: 1µg/ml for 2hrs.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    This antibody is stored in PBS, 50% glycerol

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C
  • Shao, Nadel: "Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 3, pp. 767-72, (2005) (PubMed).

    Shao, Ueki, Nadel: "Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 20, pp. 11618-23, (2003) (PubMed).

    Gschwind, Hart, Fischer, Ullrich: "TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells." in: The EMBO journal, Vol. 22, Issue 10, pp. 2411-21, (2003) (PubMed).

  • 抗原

    ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

    别名

    ADAM17

    背景

    The ADAM17 (a disintegrin and metalloprotease (ADAM) domain 17) is a member of the ADAM protein family. Members of this family are membraneanchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The ADAM17 functions as a tumor necrosis factor-alpha converting enzyme.It binds mitotic arrest deficient 2 protein and also plays a prominent role in the activation of the Notch signaling pathway.

    途径

    Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus
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