alpha 2 Macroglobulin 抗体 (C-Term)
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Quick Overview for alpha 2 Macroglobulin 抗体 (C-Term) (ABIN965491)
抗原
See all alpha 2 Macroglobulin (A2M) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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纯化方法
- Purified by antigen-specific affinity chromatography.
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免疫原
- Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human A2M (Alpha-2-macroglobulin precursor)
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应用备注
- ELISA, Western blotting: 1µg/ml for 2hrs.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- This antibody is stored in PBS, 50% glycerol
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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: "Assembly of the endoplasmic reticulum phospholipid bilayer: the phosphatidylcholine transporter." in: Cell, Vol. 42, Issue 1, pp. 51-60, (1985) (PubMed).
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: "Assembly of the endoplasmic reticulum phospholipid bilayer: the phosphatidylcholine transporter." in: Cell, Vol. 42, Issue 1, pp. 51-60, (1985) (PubMed).
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- alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))
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别名
- A2M
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背景
- A2M(Alpha-2-macroglobulin is able to inhibit all four classes of proteinases by a unique trapping mechanism. This protein has a peptide stretch, called the `bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thiolester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
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途径
- Lipid Metabolism
抗原
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