XBP1 抗体 (C-Term)
Quick Overview for XBP1 抗体 (C-Term) (ABIN955595)
抗原
See all XBP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 224-252, C-Term
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特异性
- This antibody detects XBP1 / TREB5 (C-term).
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse
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纯化方法
- Protein A column followed by peptide affinity purification
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免疫原
- KLH conjugated synthetic peptide between 224-252 amino acids from the C-terminal region of human XBP1
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亚型
- Ig Fraction
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anti-X-Box Binding Protein 1 (XBP1) antibody
XBP1 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 62-91) antibodyXBP1 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 51-150) antibodyXBP1 适用: 人, 小鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) (Internal Region) antibodyVerified XBP1 适用: 人 WB, ELISA, IHC, IF 宿主: 山羊 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 1-167) antibodyXBP1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 1-261) antibodyXBP1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 123-225) antibodyXBP1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3F5 unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 62-91) antibodyXBP1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21824 unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 1-261) antibodyXBP1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) (C-Term) antibodyXBP1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS with 0.09 % (W/V) sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
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- XBP1 (X-Box Binding Protein 1 (XBP1))
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别名
- XBP1 / TREB5
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背景
- This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.Synonyms: Tax-responsive element-binding protein 5, X-box-binding protein 1, XBP-1, XBP2
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基因ID
- 7494
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NCBI登录号
- NP_001073007
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途径
- ER-Nucleus Signaling, Unfolded Protein Response
抗原
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