XBP1 抗体 (N-Term)
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- 抗原 See all XBP1 抗体
- XBP1 (X-Box Binding Protein 1 (XBP1))
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抗原表位
- AA 59-85, N-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This XBP1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 原理
- Rabbit IgG polyclonal antibody for X-box-binding protein 1(XBP1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
- 序列
- RKRQRLTHLS PEEKALRRKL KNRVAAQ
- 交叉反应 （详细）
- No cross reactivity with other proteins.
- 产品特性
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Rabbit IgG polyclonal antibody for X-box-binding protein 1(XBP1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: X-box binding protein 1
Protein Name: X-box-binding protein 1 - 纯化方法
- Immunogen affinity purified.
- 免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human XBP1 (59-85 aa RKRQRLTHLSPEEKALRRKLKNRVAAQ), identical to the related mouse and rat sequences.
- 亚型
- IgG
- Top Product
- Discover our top product XBP1 Primary Antibody
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anti-X-Box Binding Protein 1 (XBP1) (AA 300-376) antibody
XBP1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) antibodyXBP1 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 62-91) antibodyXBP1 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 51-150) antibodyXBP1 适用: 人, 小鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) (Internal Region) antibodyVerified XBP1 适用: 人 WB, ELISA, IHC, IF 宿主: 山羊 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 1-167) antibodyXBP1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 1-261) antibodyXBP1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 123-225) antibodyXBP1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3F5 unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 62-91) antibodyXBP1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21824 unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 1-261) antibodyXBP1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for XBP1 is approximately 0.1 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users. - 说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- 浓度
- 500 μg/mL
- 缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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- 抗原
- XBP1 (X-Box Binding Protein 1 (XBP1))
- 别名
- XBP1 (XBP1 产品)
- 别名
- treb5 antibody, xXBP1 antibody, xbp2 antibody, XBP1P1 antibody, XBPP1 antibody, xbp1 antibody, TREB5 antibody, XBP-1 antibody, XBP2 antibody, D11Ertd39e antibody, TREB-5 antibody, HTF antibody, cb918 antibody, id:ibd1195 antibody, trebf antibody, wu:fb02h05 antibody, wu:fb63f10 antibody, xbp1a antibody, xbp1b antibody, X-box binding protein 1 antibody, X-box binding protein 1 L homeolog antibody, xbp1 antibody, XBP1 antibody, Xbp1 antibody, xbp1.L antibody
- 背景
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XBP1, also known as X-box binding protein 1, is a protein which in humans is encoded by the XBP1 gene. It encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.
Synonyms: Tax responsive element binding protein 5 antibody|Tax-responsive element-binding protein 5 antibody|TREB5 antibody|X box binding protein 1 antibody|X box binding protein 2 antibody| X-box-binding protein 1 antibody|XBP 1 antibody|XBP-1 antibody|XBP1 antibody|XBP1_HUMAN antibody|XBP2 antibody|XBP2 antibody - 基因ID
- 7494
- UniProt
- P17861
- 途径
- ER-Nucleus Signaling, Unfolded Protein Response
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