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CD73 抗体

NT5E 适用: 人 FACS 宿主: 小鼠 Monoclonal AD2 unconjugated
产品编号 ABIN951383
发货至: 中国
  • 抗原 See all CD73 (NT5E) 抗体
    CD73 (NT5E) (5'-Nucleotidase, Ecto (CD73) (NT5E))
    适用
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    宿主
    • 91
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    小鼠
    克隆类型
    • 81
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    单克隆
    标记
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    This CD73 antibody is un-conjugated
    应用范围
    • 83
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    Flow Cytometry (FACS)
    特异性
    This antibody recognizes CD73, a 70 kDa GPI-anchored 5´-nucleotidase expressed predominantly on T and B cell subsets, follicular dendritic cells and endothelial cells.
    交叉反应 (详细)
    Species reactivity (tested):Human
    纯化方法
    Protein A affinity chromatography
    克隆位点
    AD2
    亚型
    IgG1
    Top Product
    Discover our top product NT5E Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
  • 抗原
    CD73 (NT5E) (5'-Nucleotidase, Ecto (CD73) (NT5E))
    别名
    CD73 (NT5E 产品)
    背景
    CD73 (ecto-5´-nucleotidase) is a 70 kDa glycoprotein anchored to the extracellular leaflet of the plasma membrane by GPI. This ecto-enzyme catalyzes dephosphorylation of AMP to adenosine. CD73 is expressed in various types of cells, such as epithelial, muscle, and endothelial cells, neutrophils, lymphocytes and fibroblasts. Inflammatory mediators support CD73 expression and its enzymatic activity, leading to the release of adenosine, which modulates inflammation through adenosine receptors. CD73 is expressed in a variety of lymphomas and leukemias, including ALL and CLL, whereas immunodeficient patients usually express low levels of this protein.Synonyms: 5'-nucleotidase, NT5, NT5E, NTE
    基因ID
    4907
    NCBI登录号
    NP_001191742
    UniProt
    P21589
    途径
    Synaptic Membrane, Ribonucleoside Biosynthetic Process
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