MUC1 抗体 (AA 1209-1239)
Quick Overview for MUC1 抗体 (AA 1209-1239) (ABIN951233)
抗原
See all MUC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1209-1239
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特异性
- This antibody recognizes human CD227 / Mucin-1 / MUC1.
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纯化方法
- Purified through a Protein A column followed by peptide affinity purification
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免疫原
- Synthetic peptide - KLH conjugated - corresponding to human CD227 / Mucin-1 / MUC1 (between 1209-1239aa)
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亚型
- Ig Fraction
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS with 0.09 % (W/V) Sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- MUC1 (Mucin 1 (MUC1))
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别名
- CD227 / Mucin-1 / MUC1
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背景
- The MUC1 gene is a member of the mucin family and encodes a membrane bound, glyco- sylated phosphoprotein anchored to the apical surface of many epithelia by a transmem- brane domain, with the degree of glycosylation varying with cell type. It includes a 20aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Its overexpression, aberrant intracellular localization and changes in glycosylation have been associated with carcino- mas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined.Synonyms: Breast carcinoma-associated antigen DF3, CA 15-3, Carcinoma-associated mucin, DF3, EMA, Episialin, H23AG, MUC-1, PEMT, PUM, Peanut-reactive urinary mucin, Polymorphic epithelial mucin, Tumor-associated epithelial membrane antigen, Tumor-associated mucin
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分子量
- 122102 Da
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基因ID
- 4582
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NCBI登录号
- NP_001018016
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途径
- Negative Regulation of intrinsic apoptotic Signaling
抗原
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