HSD11B2 抗体 (Middle Region)
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Quick Overview for HSD11B2 抗体 (Middle Region) (ABIN950176)
抗原
See all HSD11B2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 284-314, Middle Region
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交叉反应 （详细）
- Species reactivity (tested):Human
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纯化方法
- This antibody is purified through a protein A column; followed by peptide affinity purification.
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免疫原
- KLH conjugated synthetic peptide between 284~314 amino acids from the Central region of human HSD11B2.
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亚型
- Ig Fraction
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anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) (AA 151-250) antibody
HSD11B2 适用: 小鼠, 大鼠, 马 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) (AA 1-405) antibodyHSD11B2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) (AA 277-309), (C-Term) antibodyHSD11B2 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (fro), IF 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) (N-Term) antibodyHSD11B2 适用: 人, 小鼠, 大鼠, 马, Cow, 豚鼠, 兔, 绵羊 WB 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) (AA 212-343) antibodyHSD11B2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) antibodyHSD11B2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) (AA 1-405) antibodyHSD11B2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) (AA 277-306) antibodyHSD11B2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB24535 unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) (AA 266-405) antibodyHSD11B2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) (N-Term) antibodyHSD11B2 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 兔, 绵羊, Bat, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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- HSD11B2 (Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))
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别名
- 11-beta HSD2 / HSD11B2
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背景
- There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.Synonyms: 11-DH2, 11-beta-hydroxysteroid dehydrogenase 2, Corticosteroid 11-beta-dehydrogenase isozyme 2, HSD11K, NAD-dependent 11-beta-hydroxysteroid dehydrogenase
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基因ID
- 3291
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NCBI登录号
- NP_000187
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途径
- Steroid Hormone Biosynthesis, Regulation of Systemic Arterial Blood Pressure by Hormones
抗原
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