BARD1 抗体
Our Local Distributor
北京 101111
Quick Overview for BARD1 抗体 (ABIN930988)
抗原
See all BARD1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
交叉反应
- 人
-
交叉反应 （详细）
- Other species not studied.
-
纯化方法
- Protein G affinity chromatography
-
免疫原
- BARD1 antibody was raised in mouse using recombinant Human Brca1 Associated Ring Domain 1 (Bard1)
-
亚型
- IgG1
-
-
anti-BRCA1 Associated RING Domain 1 (BARD1) (AA 101-200) antibody
BARD1 适用: 人 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-BRCA1 Associated RING Domain 1 (BARD1) antibodyBARD1 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 25GB8095 unconjugated
anti-BRCA1 Associated RING Domain 1 (BARD1) (AA 658-757) antibodyBARD1 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 2A11 unconjugated
anti-BRCA1 Associated RING Domain 1 (BARD1) (N-Term) antibodyBARD1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-BRCA1 Associated RING Domain 1 (BARD1) (N-Term) antibodyBARD1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-BRCA1 Associated RING Domain 1 (BARD1) (AA 428-777) antibodyBARD1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-BRCA1 Associated RING Domain 1 (BARD1) (AA 1-80) antibodyBARD1 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
WB: 0.2-2 µg/mL, IP: 100-500 µg/sample
Optimal conditions should be determined by the investigator. -
限制
- 仅限研究用
-
-
-
浓度
- Lot specific
-
缓冲液
- BARD1 antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1 % bovine serum albumin (BSA) and 0.05 % sodium azide (NaN3 ).
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
注意事项
-
Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use. -
储存条件
- 4 °C/-20 °C
-
储存方法
- Store at 2-8 °C for up to one year. We recommend long term storage at -20 °C.
-
-
- BARD1 (BRCA1 Associated RING Domain 1 (BARD1))
-
别名
- BARD1
-
背景
- BARD1 interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, BARD1 shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. The BARD1 protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. BARD1 may be the target of oncogenic mutations in breast or ovarian cancer. Synonyms: Monoclonal BARD1 antibody, Anti-BARD1 antibody, BRCA1 associated RING domain gene 1 antibody.
-
途径
- DNA Damage Repair
抗原
-
