PIDD 抗体 (AA 551-650) (Biotin)
Quick Overview for PIDD 抗体 (AA 551-650) (Biotin) (ABIN905096)
抗原
See all PIDD 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 551-650
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交叉反应
- 大鼠
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预测反应
- Human,Mouse
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human LRDD/PIDD
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亚型
- IgG
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anti-P53-Induced Death Domain Protein (PIDD) (AA 1-85) antibody
PIDD 适用: 人 IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-P53-Induced Death Domain Protein (PIDD) antibodyPIDD 适用: 人, 大鼠, 小鼠 IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-P53-Induced Death Domain Protein (PIDD) (AA 694-885) antibodyPIDD 适用: 人 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-P53-Induced Death Domain Protein (PIDD) (AA 666-915) antibodyPIDD 适用: 小鼠 IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-P53-Induced Death Domain Protein (PIDD) (AA 776-910) antibodyPIDD 适用: 人 ELISA 宿主: 小鼠 Monoclonal 3C5G8 unconjugated
anti-P53-Induced Death Domain Protein (PIDD) antibodyPIDD 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-P53-Induced Death Domain Protein (PIDD) (AA 143-192) antibodyPIDD 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-P53-Induced Death Domain Protein (PIDD) (AA 467-516) antibodyPIDD 适用: 人, 豚鼠, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-P53-Induced Death Domain Protein (PIDD) (AA 668-917) antibodyPIDD 适用: 大鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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IHC-P 1:200-400
IHC-F 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- PIDD (P53-Induced Death Domain Protein (PIDD))
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别名
- LRDD
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背景
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Synonyms: Leucine rich repeats and death domain containing, Leucine-rich repeats and death domain containing, MGC16925, p53-induced protein with a death domain, PIDD, DKFZp434D229, PIDD_HUMAN.
Background: The death domain (DD) containing protein PIDD is a p53 target gene in an erythroleukemia cell line that undergoes G1 phase arrest and subsequent apoptosis after p53 expression. Independently, PIDD was also described as a DD-containing protein with unknown function. The N-terminal region of PIDD contains seven leucine-rich repeats (LRRs), a protein interaction motif found in various proteins with diverse functions, followed by two ZU-5 domains and a C-terminal DD. PIDD forms a complex with caspase-2 and the adaptor protein RAIDD. Increased PIDD expression results in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli, via interaction with caspase-2 and CRADD/RAIDD. PIDD also promotes apoptosis downstream of p53 as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. PIDD has also been shown to interact with NEMO/IKBKG and RIP1 and enhance sumoylation and ubiquitination of NEMO/IKBKG, an important component for activation of the transcription factor NF-kappa-B.
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途径
- p53 Pathway, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
抗原
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