EPH Receptor A4 抗体 (AA 531-630) (AbBy Fluor® 488)
Quick Overview for EPH Receptor A4 抗体 (AA 531-630) (AbBy Fluor® 488) (ABIN895462)
抗原
See all EPH Receptor A4 (EPHA4) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 531-630
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交叉反应
- 大鼠
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预测反应
- Human,Mouse,Dog,Pig,Horse,Chicken,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human EphA4
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亚型
- IgG
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anti-EPH Receptor A4 (EPHA4) (AA 40-70), (N-Term) antibody
EPHA4 适用: 人 WB, IHC (p), IF, FACS 宿主: 兔 Polyclonal RB1587 unconjugated
anti-EPH Receptor A4 (EPHA4) (AA 621-882) antibodyEPHA4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A4 (EPHA4) (AA 345-545) antibodyEPHA4 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A4 (EPHA4) (AA 887-986) antibodyEPHA4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6H7 unconjugated
anti-EPH Receptor A4 (EPHA4) antibodyEPHA4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A4 (EPHA4) (AA 531-630) antibodyEPHA4 适用: 大鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A4 (EPHA4) (AA 383-417) antibodyEPHA4 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB50832 unconjugated
anti-EPH Receptor A4 (EPHA4) (Internal Region) antibodyEPHA4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A4 (EPHA4) (AA 887-986) antibodyEPHA4 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A4 (EPHA4) (AA 777-986) antibodyEPHA4 适用: 人 ELISA 宿主: 小鼠 Monoclonal 7D3D4 unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- EPH Receptor A4 (EPHA4)
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别名
- Eph Receptor A4
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背景
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Synonyms: SEK, HEK8, TYRO1, Ephrin type-A receptor 4, EPH-like kinase 8, EK8, Tyrosine-protein kinase TYRO1, Tyrosine-protein kinase receptor SEK, EPHA4
Background: Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.
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基因ID
- 2043
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UniProt
- P54764
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途径
- RTK signaling
抗原
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