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Src 抗体 (pTyr418) (AbBy Fluor® 647)

Name: Src 抗体 (pTyr418) (AbBy Fluor® 647)
SKU: ABIN879678
Availability: OutOfStock

This anti-Src antibody is a 兔多克隆 antibody detecting Src in WB, IF (cc), IF (p) 和 FACS. Suitable for 人, 小鼠和大鼠.

产品编号 ABIN879678

发货至: 中国

Quick Overview for Src 抗体 (pTyr418) (AbBy Fluor® 647) (ABIN879678)

抗原

See all Src 抗体

Src (Proto-oncogene tyrosine-protein kinase Src (Src))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This Src antibody is conjugated to AbBy Fluor® 647

应用范围

Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS)

Discover our top product Src Primary Antibody

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pTyr418

特异性

Due to the highly conserved nature of this protein, this antibody will react with the related proteins LCK(Tyr394), Lyn (Tyr397), and YES1(Tyr426) if phosphorylated at this site due to homology.

交叉反应

人, 小鼠, 大鼠

预测反应

Sheep,Pig,Chicken

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic phosphopeptide derived from human Src around the phosphorylation site of Tyr418

亚型

IgG
anti-Proto-oncogene tyrosine-protein kinase Src (Src) antibody
Src 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 1F11 unconjugated

anti-Proto-oncogene tyrosine-protein kinase Src (Src) (pTyr530) antibody
Src 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Proto-oncogene tyrosine-protein kinase Src (Src) (AA 1-80) antibody
Src 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Proto-oncogene tyrosine-protein kinase Src (Src) antibody
Src 适用: 人, 小鼠 WB, IF 宿主: 小鼠 Monoclonal 17AT28 unconjugated

anti-Proto-oncogene tyrosine-protein kinase Src (Src) (AA 24-52), (N-Term) antibody
Src 适用: 人 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB41141 unconjugated

anti-Proto-oncogene tyrosine-protein kinase Src (Src) antibody
KO Validated Src 适用: 人 WB, IF, IP 宿主: 兔 Monoclonal unconjugated

anti-Proto-oncogene tyrosine-protein kinase Src (Src) (AA 24-52) antibody
Src 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-Proto-oncogene tyrosine-protein kinase Src (Src) (AA 397-424) antibody
Src 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Proto-oncogene tyrosine-protein kinase Src (Src) (pTyr529) antibody
Src 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Proto-oncogene tyrosine-protein kinase Src (Src) (AA 1-90) antibody
Src 适用: 人 WB, ELISA, IF, IHC (p), PLA 宿主: 小鼠 Monoclonal 1B9 unconjugated

应用备注

FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

有效期

12 months
抗原

Src (Proto-oncogene tyrosine-protein kinase Src (Src))

别名

Src

背景

Synonyms: ASV, SRC1, c-SRC, p60-Src, Proto-oncogene tyrosine-protein kinase Src, Proto-oncogene c-Src, pp60c-src, SRC
Background: Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption, this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation, this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels.

基因ID

6714

UniProt

P12931

途径

JAK/STAT Signaling, Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization, Regulation of Carbohydrate Metabolic Process, Autophagy, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling, Platelet-derived growth Factor Receptor Signaling, Thromboxane A2 Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling