MAP2K5 抗体 (AA 311-315)
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Quick Overview for MAP2K5 抗体 (AA 311-315) (ABIN871696)
抗原
See all MAP2K5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 311-315
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特异性
- The antibody detects endogenous level of total MEK5 protein.
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纯化方法
- Affinity purified
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免疫原
- Peptide sequence around AA 311-315 (K-T-Y-V-G ) derived from Rat MEK5. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
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应用备注
- Western blotting: 1:500
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))
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别名
- MEK5
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背景
- A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phospho-rylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resem-bles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphory-late ERK5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway.
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分子量
- 49 kDa
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基因ID
- 29568
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NCBI登录号
- NP_001029
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UniProt
- Q62862
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途径
- MAPK Pathway, Neurotrophin Signaling Pathway
抗原
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