MCL-1 抗体 (AA 121-139)
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Quick Overview for MCL-1 抗体 (AA 121-139) (ABIN783904)
抗原
See all MCL-1 (MCL1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 121-139
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特异性
- This antibody reacts to Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1).
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纯化方法
- Immunoaffinity Chromatography
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免疫原
- A synthetic peptide corresponding to aa 121-139 of human Mcl-1 Genename: MCL1
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 10 mM PBS, pH 7.4 containing 1 % BSA as stabilizer and 0,09 % sodium azide as preservative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
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- MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))
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别名
- MCL1
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背景
- Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival. While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak. Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis (5) and for the development and maintenance of B and T lymphocytes in animals. Mcl-1 exists as at least two distinct isoforms designated Mcl-1L and Mcl-1S. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death.Synonyms: BCL2L3, Bcl-2-like protein 3, Bcl-2-related protein, EAT, Induced myeloid leukemia cell differentiation protein Mcl-1, mcl1/EAT, r004
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基因ID
- 4170
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NCBI登录号
- NP_001184249
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途径
- MAPK Pathway
抗原
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