IDH2 抗体 (N-Term)
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Quick Overview for IDH2 抗体 (N-Term) (ABIN783628)
抗原
See all IDH2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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交叉反应 (详细)
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- 17 amino acid peptide near the amino terminus of human IDH2
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store the antibody (in aliquots) at -20 °C.
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- IDH2 (Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2))
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别名
- Isocitrate Dehydrogenase / IDH2
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背景
- Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Two NADP(+)-dependent isocitrate dehydrogenases have been found as homodimer: IDH1 is predominantly cytosolic and peroxisomal and IDH2 is mitochondrial. Both IDH1 and IDH2 play significant roles in the tricarboxylic acid cycle (TCA), and defects in IDH1 as well as IDH2 have been implicated in the development of glioma as well as other malignancies.Synonyms: ICD-M, ICDH, IDP, NADP(+)-specific ICDH, mitochondrial Isocitrate dehydrogenase [NADP], mitochondrial Oxalosuccinate decarboxylase
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基因ID
- 3418
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NCBI登录号
- NP_002159
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UniProt
- P48735
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途径
- Warburg Effect
抗原
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