EZH2 抗体 (N-Term)
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Quick Overview for EZH2 抗体 (N-Term) (ABIN783462)
抗原
See all EZH2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- This antibody detects EZH2 / KMT6 N-term. EZH2 antibody is predicted to not cross-react with EZH1.
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交叉反应 (详细)
- Species reactivity (tested):Human, mouse
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- 17 amino acid peptide near the amino terminus of human EZH2
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
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- EZH2 (Enhancer of Zeste Homolog 2 (EZH2))
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别名
- EZH2 / KMT6
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背景
- EZH2 was initially identified as a homolog of the drosophila Enhancer of Zeste through exon trap screening of chromosome 21. Both EZH2 and the related protein EZH1 can form complexes with the noncanonical Polycomb repressive complex-2 (PRC2) and maintain repressive chromatin, but the PRC2-EZH1 complex mediates methylation of histone H3. Both EZH1 and EZH2 are thought to function in the maintenance of embryonic stem cell pluripotency and plasticity and recently have been shown to be essential for hair follicle homeostasis and wound repair. Overexpression of EZH2 has been reported as a marker for advanced and metastatic cancers. Multiple isoforms of EZH2 are known to exist.Synonyms: ENX-1, Enhancer of zeste homolog 2, Histone-lysine N-methyltransferase EZH2, Lysine N-methyltransferase 6
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基因ID
- 2146
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NCBI登录号
- NP_001190176
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UniProt
- Q15910
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途径
- Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation
抗原
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