BMI1 抗体
Our Local Distributor
北京 101111
Quick Overview for BMI1 抗体 (ABIN781174)
抗原
See all BMI1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
特异性
- Nucleus
-
纯化方法
- Protein G-Sepharose affinity purified
-
免疫原
- Synthetic peptide from the N-terminal region of human Bmi1, conjugated to KLH.
-
亚型
- IgG
-
-
-
-
应用备注
- Recommended dilutions. ELISA: 1/5000 - 1/20000. WB: 1/100-1/2000.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 50µg/50µl
-
缓冲液
- 0.02% Sodium Azide and 50% glycerol, 1% BSA, PBS, pH7.4.
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
-
- BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))
-
别名
- Bmi1
-
背景
- The Bmi1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. Bmi1 plays a central role in the inheritance of stemness, and its forced expression promotes HSC self-renewal. These findings highlight the importance of epigenetic regulation in HSC self-renewal and identify PcG genes as potential targets for therapeutic HSC manipulation.
-
分子量
- 37kDa
-
NCBI登录号
- NM_005180
-
途径
- Cell Division Cycle, Autophagy
抗原
-