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RAD50 抗体 (pSer635)

The 兔 多克隆 anti-RAD50 antibody is suitable to detect RAD50 in samples from 人, 小鼠 和 大鼠. It has been validated for WB 和 IHC.
产品编号 ABIN8124222
发货至: 中国
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Quick Overview for RAD50 抗体 (pSer635) (ABIN8124222)

抗原

See all RAD50 抗体
RAD50 (RAD50 Homolog (S. Cerevisiae) (RAD50))

适用

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人, 小鼠, 大鼠

宿主

  • 96
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兔

克隆类型

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多克隆

标记

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This RAD50 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC)
  • 抗原表位

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    pSer635

    原理

    Rad50 (Phospho Ser635) Antibody

    特异性

    This antibody detects endogenous levels of Human Rad50 (phospho-Ser635)

    纯化方法

    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

    免疫原

    Synthesized phosho peptide around human Rad50 (Ser635)

    亚型

    IgG
  • 应用备注

    WB 1:500-2000,IHC 1:50-300

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C/1 year

    有效期

    12 months
  • 抗原

    RAD50 (RAD50 Homolog (S. Cerevisiae) (RAD50))

    别名

    Rad50

    背景

    Synonyms: DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-)

    Background: RAD50 double strand break repair protein(RAD50) Homo sapiens The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010],

    Gene Name: RAD50

    Protein Name: Rad50 (Ser635)

    基因ID

    10111

    UniProt

    Q92878

    途径

    DNA Damage Repair, Protein targeting to Nucleus
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