POU2AF1 抗体 (AA 201-250)
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Quick Overview for POU2AF1 抗体 (AA 201-250) (ABIN8123907)
抗原
See all POU2AF1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 201-250
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原理
- Bob 1 Antibody
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特异性
- The antibody detects endogenous Bob 1
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- Synthetic peptide from human protein at AA range: 201-250
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亚型
- IgG
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应用备注
- IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- POU2AF1 (POU Class 2 Associating Factor 1 (POU2AF1))
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别名
- Bob 1
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背景
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Synonyms: POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1, BOB-1, OCA-B, OCT-binding factor 1)
Background: disease:A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3,11)(q27,q23) with BCL6.,function:Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.,PTM:Ubiquitinated, mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the POU2AF1 family.,tissue specificity:B-cell specific.,
Gene Name: POU2AF1 OBF1
Protein Name: POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (BOB-1) (OCA-B) (OCT-binding factor 1)
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基因ID
- 5450
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UniProt
- Q16633
抗原
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