POLH 抗体
Our Local Distributor
北京 101111
Quick Overview for POLH 抗体 (ABIN8123858)
抗原
See all POLH 抗体适用
宿主
克隆类型
标记
应用范围
-
-
原理
- POLH Antibody
-
特异性
- POLH Polyclonal Antibody detects endogenous levels of protein.
-
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-
免疫原
- Synthesized peptide derived from part region of human protein
-
亚型
- IgG
-
-
-
-
应用备注
- WB 1:500-2000 ELISA 1:5000-20000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Liquid in PBS containing 50 % glycerol, and 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C/1 year
-
有效期
- 12 months
-
-
- POLH (Polymerase (DNA Directed), eta (POLH))
-
别名
- POLH
-
背景
-
Background: This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA, when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014],
Gene Name: POLH RAD30 RAD30A XPV
Protein Name: DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein)
-
基因ID
- 5429
-
UniProt
- Q9Y253
-
途径
- DNA Damage Repair
抗原
-