POLB 抗体 (acLys72)
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北京 101111
Quick Overview for POLB 抗体 (acLys72) (ABIN8123855)
抗原
See all POLB 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- acLys72
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原理
- DNA pol β (Acetyl Lys72) Antibody
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特异性
- This antibody detects endogenous levels of Human,Mouse,Rat DNA pol β (Acetyl Lys72)
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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免疫原
- Synthesized peptide derived from human DNA pol beta (Acetyl Lys72)
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亚型
- IgG
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应用备注
- WB 1:1000-2000 ELISA 1:5000-20000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- POLB (Polymerase (DNA Directed), beta (POLB))
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别名
- DNA pol beta
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背景
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Synonyms: DNA polymerase beta (EC 2.7.7.7, EC 4.2.99.-)
Background: catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,cofactor:Binds 2 magnesium ions per subunit.,domain:Residues 239-252 form a flexible loop which appears to affect the polymerase fidelity.,function:Repair polymerase. Conducts "gap-filling" DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.,PTM:Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity.,similarity:Belongs to the DNA polymerase type-X family.,subunit:Monomer.,
Gene Name: POLB
Protein Name: DNA pol β (Acetyl Lys72)
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基因ID
- 5423
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UniProt
- P06746
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途径
- DNA Damage Repair
抗原
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