LRP6 抗体 (pSer1490)
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北京 101111
Quick Overview for LRP6 抗体 (pSer1490) (ABIN8122680)
抗原
See all LRP6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer1490
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原理
- LRP6 (Phospho Ser1490) Antibody
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特异性
- This antibody detects endogenous levels of Human LRP6 (phospho-Ser1490)
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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免疫原
- Synthesized phosho peptide around human LRP6 (Ser1490)
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亚型
- IgG
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应用备注
- WB 1:500-2000,IHC 1:50-300
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))
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别名
- LRP6
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背景
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Synonyms: Low-density lipoprotein receptor-related protein 6 (LRP-6)
Background: This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands.The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009],
Gene Name: LRP6
Protein Name: LRP6 (Ser1490)
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基因ID
- 4040
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UniProt
- O75581
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途径
- WNT signaling, Tube Formation
抗原
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