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LRP6 抗体 (C-Term)

LRP6 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6263009
发货至: 中国
  • 抗原 See all LRP6 抗体
    LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))
    抗原表位
    • 17
    • 16
    • 8
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 57
    • 36
    • 17
    • 2
    • 2
    人, 小鼠, 大鼠
    宿主
    • 54
    • 3
    • 1
    • 1
    克隆类型
    • 56
    • 3
    多克隆
    标记
    • 24
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This LRP6 antibody is un-conjugated
    应用范围
    • 53
    • 26
    • 26
    • 21
    • 17
    • 16
    • 8
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    特异性
    LRP6 Antibody detects endogenous levels of total LRP6.
    预测反应
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human LRP6, corresponding to a region within C-terminal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product LRP6 Primary Antibody
  • 应用备注
    WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • Zhu, Wang, Zhao, Zhang, Wu, Wang, Hu: "Rottlerin as a novel chemotherapy agent for adrenocortical carcinoma." in: Oncotarget, Vol. 8, Issue 14, pp. 22825-22834, (2017) (PubMed).

  • 抗原
    LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))
    别名
    LRP6 (LRP6 产品)
    别名
    lrp6-A antibody, Xlrp6 antibody, adcad2 antibody, lrp6 antibody, LRP6 antibody, ADCAD2 antibody, C030016K15Rik antibody, Cd antibody, Gw antibody, LDL receptor related protein 6 antibody, LDL receptor related protein 6 L homeolog antibody, LDL receptor related protein 6 S homeolog antibody, low density lipoprotein receptor-related protein 6 antibody, low-density lipoprotein receptor-related protein 6 antibody, LRP6 antibody, lrp6.L antibody, lrp6.S antibody, lrp6 antibody, Lrp6 antibody, LOC590395 antibody
    背景

    Description: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).

    Gene: LRP6

    分子量
    180 kDa
    基因ID
    4040
    UniProt
    O75581
    途径
    WNT signaling, Tube Formation
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