CD42b 抗体 (AA 500-627)
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Quick Overview for CD42b 抗体 (AA 500-627) (ABIN8121768)
抗原
See all CD42b (GP1BA) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 500-627
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原理
- CD42b mouse mAb
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特异性
- This antibody detects endogenous levels of CD42b protein.
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纯化方法
- The antibody was purified by protein G affinity chromatography.
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免疫原
- A synthetic peptide corresponding to the amino acid region 500 - 627 of the human CD42b protein.
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亚型
- IgG
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应用备注
- IHC, 1:200-1:1000 | IF, 1:100-1:500 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid freeze / thaw cycles
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储存条件
- -20 °C
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储存方法
- Store at-20°C. Avoid freeze / thaw cycles.
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- CD42b (GP1BA) (Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA))
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别名
- CD42b
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背景
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Synonyms: GP1BA, Platelet glycoprotein Ib alpha chain, GP-Ib alpha, GPIb-alpha, GPIbA, Glycoprotein Ibalpha, Antigen CD42b-alpha, CD42b,
Background: Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF) . The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is
Gene Name: GP1BA
Protein Name: CD42b
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基因ID
- 2811
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UniProt
- P07359
抗原
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