FASL 抗体 (AA 121-170)
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北京 101111
Quick Overview for FASL 抗体 (AA 121-170) (ABIN8121390)
抗原
See all FASL 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 121-170
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原理
- FAS-L Antibody
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特异性
- The antibody detects endogenous FAS-L
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- Synthetic peptide from human protein at AA range: 121-170
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亚型
- IgG
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应用备注
- IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))
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别名
- FAS-L
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背景
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Synonyms: Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand, APTL, CD95 ligand, CD95-L, Fas antigen ligand, Fas ligand, FasL, CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form, Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain, Soluble Fas ligand, sFasL), ADAM10-processed FasL form (APL), FasL intracellular domain (FasL ICD, SPPL2A-processed FasL form, SPA)]
Background: This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014],
Gene Name: FASLG APT1LG1 CD95L FASL TNFSF6
Protein Name: Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand) (APTL) (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane formTumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL)ADAM10-processed FasL form (APL)FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]
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基因ID
- 356
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UniProt
- P48023
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途径
- Apoptosis, EGFR Signaling Pathway, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
抗原
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