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FASL 抗体

Name: FASL 抗体
Brand: antibodies-online
SKU: ABIN2749018
Availability: OutOfStock

FASL 适用: 人 WB, FACS, IP, ICC, Func 宿主: 小鼠 Monoclonal NOK-1 unconjugated

Flow cytometry surface staining pattern of FasL transfected L5178Y cells stained using anti-human CD178 (NOK-1) purified antibody (low endotoxin, concentration in sample 9 μg/mL) GAM APC. (FASL 抗体)

FACS

Separation of FasL transfected L5178Y cells stained using anti-human CD178 (NOK-1) purified antibody (low endotoxin, concentration in sample 9 μg/mL, GAM APC, red-filled) from FasL transfected L5178Y cells unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining). (FASL 抗体)

FACS

2 images

(5 references)

产品编号 ABIN2749018

发货至: 中国

Datasheet as PDF

抗原 See all FASL 抗体

FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))
适用
96

47

34

18

6

4

3

2

1
人
宿主
68

27

10

5

4

1
小鼠
Compatible Secondaries
克隆类型
75

40
单克隆
标记
65

12

10

6

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This FASL antibody is un-conjugated
应用范围
77

52

26

22

20

16

13

13

10

7

5

5

4

4

4

2

2

2

1

1

1

1

1

1
Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunocytochemistry (ICC), Functional Studies (Func)

特异性

The mouse monoclonal antibody NOK-1 recognizes an extracellular epitope of CD178 / Fas-L, an approximately 40 kDa transmembrane glycoprotein expressed on neutrophils, monocytes, and activated T and NK cells.

交叉反应（详细）

Human

纯化方法

Purified by protein-A affinity chromatography.

纯度

> 95 % (by SDS-PAGE)

内毒素水平

Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.

免疫原

L5178Y mouse T lymphoma cells expressing recombinant human CD178

克隆位点

NOK-1

亚型

IgG1

Top Product

Discover our top product FASL Primary Antibody
anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) (AA 196-281) antibody
FASL 适用: 人, 小鼠, 大鼠, Pig WB, FACS, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) (AA 100-200) antibody
FASL 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) antibody
FASL 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) (AA 102-280) antibody
FASL 适用: 猕猴 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) (AA 100-278) antibody
FASL 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) (AA 103-281) antibody
FASL 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) (AA 82-145) antibody
FASL 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) (AA 1-281) antibody
FASL 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 2G9-G8 unconjugated

anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) antibody
FASL 适用: 人 WB, FACS, IP, ICC 宿主: 小鼠 Monoclonal NOK-1 unconjugated

anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) (AA 196-220) antibody
FASL 适用: 小鼠 WB, FACS, ICC, IF 宿主: 大鼠 Monoclonal H11 unconjugated

应用备注

Functional application: Blocking.
Flow cytometry: Recommended dilution: 1-4 μg/mL

限制

仅限研究用
浓度

1 mg/mL

缓冲液

Phosphate buffered saline (PBS), pH 7.4

储存液

Azide free

储存条件

4 °C

储存方法

Store at 2-8°C. Do not freeze.
Ji, Chen, Braciale, Cloyd: "Apoptosis induced in HIV-1-exposed, resting CD4+ T cells subsequent to signaling through homing receptors is Fas/Fas ligand-mediated." in: Journal of leukocyte biology, Vol. 81, Issue 1, pp. 297-305, (2006) (PubMed).

Jodo, Pidiyar, Xiao, Furusaki, Sharma, Koike, Ju: "Fas ligand (CD178) cytoplasmic tail is a positive regulator of Fas ligand-mediated cytotoxicity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 8, pp. 4470-4, (2005) (PubMed).

Chopin, Barei-Moniri, Maillé, Le Frère-Belda, Muscatelli-Groux, Merendino, Lecerf, Stoppacciaro, Velotti: "Human urinary bladder transitional cell carcinomas acquire the functional Fas ligand during tumor progression." in: The American journal of pathology, Vol. 162, Issue 4, pp. 1139-49, (2003) (PubMed).

Ghadimi, Sanzenbacher, Thiede, Wenzel, Jing, Plomann, Borkhardt, Kabelitz, Janssen: "Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178)." in: FEBS letters, Vol. 519, Issue 1-3, pp. 50-8, (2002) (PubMed).

Kayagaki, Kawasaki, Ebata, Ohmoto, Ikeda, Inoue, Yoshino, Okumura, Yagita: "Metalloproteinase-mediated release of human Fas ligand." in: The Journal of experimental medicine, Vol. 182, Issue 6, pp. 1777-83, (1996) (PubMed).
抗原

FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))

别名

CD178 / Fas-L (FASL 产品)

别名

ALPS1B antibody, APT1LG1 antibody, APTL antibody, CD178 antibody, CD95-L antibody, CD95L antibody, FASL antibody, TNFSF6 antibody, fasl antibody, Fas-L antibody, Faslg antibody, Tnfsf6 antibody, gld antibody, Apt1Lg1 antibody, Fasl antibody, FASLG antibody, zgc:162027 antibody, Fas ligand antibody, Fas ligand L homeolog antibody, Fas ligand (TNF superfamily, member 6) antibody, FASLG antibody, faslg.L antibody, Fasl antibody, Faslg antibody, faslg antibody

背景

Fas ligand,CD178 / Fas-L (Fas ligand, CD95L), a member of TNF family transmembrane glycoproteins, is responsible for induction of apoptosis in cells containing its receptor CD95 / Fas. The CD178-mediated apoptosis pathway has been implicated in peripheral tolerance, tissue pathology, and maintenance of the immune privileged sites. Defects in this interaction may be related to some cases of systemic lupus erythematosus (SLE). CD178 was also described as a co-stimulatory receptor for T-cell activation in mice in vivo.,APTL, FASL, FAS-ligand, CD95L, TNFSF6, TNLG1A

基因ID

356

UniProt

P48023

途径

Apoptosis, EGFR Signaling Pathway, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity