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p300 抗体 (pSer1834)

Name: p300 抗体 (pSer1834)
SKU: ABIN8121101
Availability: OutOfStock

This 兔多克隆 antibody specifically detects p300 in WB 和 ELISA. It exhibits reactivity toward 人, 小鼠和大鼠.

产品编号 ABIN8121101

发货至: 中国

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Quick Overview for p300 抗体 (pSer1834) (ABIN8121101)

抗原

See all p300 (EP300) 抗体

p300 (EP300) (E1A Binding Protein P300 (EP300))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This p300 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA

Discover our top product EP300 Primary Antibody

抗原表位
37

13

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12

9

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3

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

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1

1

1

1

1
pSer1834

原理

p300 (Phospho Ser1834) Antibody

特异性

This antibody detects endogenous levels of Human p300 (Phospho Ser1834)

纯化方法

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

免疫原

Synthesized peptide derived from human p300 (Phospho Ser1834)

亚型

IgG
anti-E1A Binding Protein P300 (EP300) (AA 731-830) antibody
EP300 适用: 人 IF, IHC (p) 宿主: 小鼠 Monoclonal 1B1 unconjugated

anti-E1A Binding Protein P300 (EP300) (Middle Region) antibody
EP300 适用: 人, 小鼠 WB, IHC, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated

anti-E1A Binding Protein P300 (EP300) (AA 2065-2414) antibody
EP300 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-E1A Binding Protein P300 (EP300) antibody
EP300 适用: 人 WB, IF, IP, ICC, ChIP, ChIP-seq 宿主: 小鼠 Monoclonal NM11 unconjugated

anti-E1A Binding Protein P300 (EP300) (N-Term) antibody
EP300 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-E1A Binding Protein P300 (EP300) (AA 1-158) antibody
EP300 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated

anti-E1A Binding Protein P300 (EP300) (AA 2283-2414) antibody
EP300 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-E1A Binding Protein P300 (EP300) (N-Term) antibody
EP300 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-E1A Binding Protein P300 (EP300) (AA 1351-1601) antibody
EP300 适用: 人 IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-E1A Binding Protein P300 (EP300) (AA 950-1000) antibody
EP300 适用: 人 IHC 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:1000-2000 ELISA 1:5000-20000

限制

仅限研究用
状态

Liquid

缓冲液

Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20°C/1 year

有效期

12 months
抗原

p300 (EP300) (E1A Binding Protein P300 (EP300))

别名

p300

背景

Synonyms: Histone acetyltransferase p300 (p300 HAT, EC 2.3.1.48, E1A-associated protein p300)
Background: catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone.,disease:Chromosomal aberrations involving EP300 may be a cause of acute myeloid leukemias. Translocation t(8,22)(p11,q13) with MYST3.,disease:Defects in EP300 are a cause of Rubinstein-Taybi syndrome (RSTS) [MIM:180849]. RSTS is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.,disease:Defects in EP300 may play a role in epithelial cancer.,function:Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.,online information:P300/CBP entry,PTM:Acetylated on Lys at up to 17 positions by intermolecular autocatalysis.,PTM:Citrullinated at Arg-2142 by PADI4, which impairs methylation by CARM1 and promotes interaction with NCOA2/GRIP1.,PTM:Methylated at Arg-580 and Arg-604 in the KIX domain by CARM1, which blocks association with CREB, inhibits CREB signaling and activates apoptotic response. Also methylated at Arg-2142 by CARM1, which impairs interaction with NCOA2/GRIP1.,PTM:Phosphorylated.,similarity:Contains 1 bromo domain.,similarity:Contains 1 KIX domain.,similarity:Contains 1 ZZ-type zinc finger.,similarity:Contains 2 TAZ-type zinc fingers.,subunit:Interacts with phosphorylated CREB1 (By similarity). Interacts with DTX1, EID1, ELF3, FEN1, LEF1, NCOA1, NCOA6, NR3C1, PCAF, PELP1, PRDM6, SPIB, SRY, TCF7L2, TP53, SRCAP, TTC5, JMY and TRERF1. The TAZ-type 1 domain interacts with HIF1A. Probably part of a complex with HIF1A and CREBBP. Part of a complex containing CARM1 and NCOA2/GRIP1. Interacts with ING4 and this interaction may be indirect. Interacts with ING5. Interacts with the C-terminal region of CITED4. Interacts with HTLV-1 Tax and p30II. Interacts with and acetylates HIV-1 Tat.,
Gene Name: EP300 P300
Protein Name: p300 (Phospho Ser1834)

基因ID

2033

UniProt

Q09472

途径

p53 Pathway, Notch Signaling, Interferon-gamma Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Regulation of Cell Size