C1S 抗体 (Cleaved-Ile438, Light Chain)
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北京 101111
Quick Overview for C1S 抗体 (Cleaved-Ile438, Light Chain) (ABIN8120712)
抗原
See all C1S 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Cleaved-Ile438, Light Chain
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原理
- C1S (light chain, Cleaved-Ile438) Antibody
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特异性
- This antibody detects endogenous levels of Human C1S (light chain, Cleaved-Ile438, protein was cleaved amino acid sequence between 437-438 )
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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免疫原
- Synthesized peptide derived from human C1S (light chain, Cleaved-Ile438)
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亚型
- IgG
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anti-Complement Component 1, S Subcomponent (C1S) (AA 1-688) antibody
C1S 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, S Subcomponent (C1S) antibodyC1S 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, S Subcomponent (C1S) antibodyC1S 适用: 人 WB, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, S Subcomponent (C1S) antibodyC1S 适用: 人 IHC, ELISA, IHC (p) 宿主: 山羊 Polyclonal unconjugated
anti-Complement Component 1, S Subcomponent (C1S) (C-Term) antibodyC1S 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, S Subcomponent (C1S) antibodyC1S 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 2F5 unconjugated
anti-Complement Component 1, S Subcomponent (C1S) (AA 1-688) antibodyC1S 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Complement Component 1, S Subcomponent (C1S) antibodyC1S 适用: 人, 大鼠, 小鼠, 猴 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2A8 unconjugated
anti-Complement Component 1, S Subcomponent (C1S) (AA 479-688) antibodyC1S 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, S Subcomponent (C1S) (cleaved), (Internal Region) antibodyC1S 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-2000 ELISA 1:5000-20000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- C1S (Complement Component 1, S Subcomponent (C1S))
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别名
- C1S
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背景
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Synonyms: Complement C1s subcomponent (EC 3.4.21.42, C1 esterase, Complement component 1 subcomponent s) [Cleaved into: Complement C1s subcomponent heavy chain, Complement C1s subcomponent light chain]
Background: catalytic activity:Cleavage of Arg-|-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b: the 'classical' pathway C3 convertase.,disease:Defects in C1S are the cause of selective C1s deficiency [MIM:120580], that is associated with early onset multiple autoimmune diseases.,enzyme regulation:Inhibited by SERPING1.,function:C1s B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.,online information:C1S mutation db,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. Activated C1s is an disulfide-linked heterodimer of a heavy chain and a light chain.,
Gene Name: C1S
Protein Name: C1S (light chain, Cleaved-Ile438)
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基因ID
- 716
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UniProt
- P09871
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途径
- Complement System
抗原
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