SYVN1 抗体 (AA 68-604)
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北京 101111
Quick Overview for SYVN1 抗体 (AA 68-604) (ABIN8093504)
抗原
See all SYVN1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 68-604
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原理
- SYVN1 Antibody / Synoviolin / HRD1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human HRD1/SYVN1 recombinant protein (amino acids Q68-R604) was used as the immunogen for the Synoviolin antibody.
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亚型
- IgG
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anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 586-617), (C-Term) antibody
SYVN1 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB4822 unconjugated
anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (Internal Region) antibodyVerified SYVN1 适用: 人, 大鼠 WB, ELISA, FACS, IF 宿主: 山羊 Polyclonal unconjugated
anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 586-617) antibodySYVN1 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 531-617) antibodySYVN1 适用: 人 WB, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (Internal Region) antibodySYVN1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 68-604) antibodySYVN1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 58-88), (N-Term) antibodySYVN1 适用: 人 WB 宿主: 兔 Polyclonal RB5086 unconjugated
anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 338-487) antibodySYVN1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (Internal Region) antibodySYVN1 适用: 人, 小鼠, 大鼠, 马, 犬, Cow, 兔, Bat, 猴, Hamster, 非洲爪蟾, 斑马鱼 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 238-318) antibodySYVN1 适用: 人 WB 宿主: 小鼠 Monoclonal 4H4 unconjugated
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应用备注
- Optimal dilution of the Synoviolin antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Synoviolin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))
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别名
- SYVN1
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背景
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Synoviolin antibody targets Synoviolin (SYVN1), also known as HRD1, an endoplasmic reticulum membrane-anchored E3 ubiquitin ligase that functions as a central component of the ER-associated degradation pathway. Synoviolin mediates the ubiquitination of misfolded or excess proteins within the endoplasmic reticulum, marking them for retrotranslocation and proteasomal degradation. The protein localizes predominantly to the ER membrane, where its cytosolic RING finger domain catalyzes ubiquitin transfer in coordination with E2 enzymes. Through this activity, Synoviolin plays a key role in maintaining ER protein quality control and cellular proteostasis.
Functionally, Synoviolin regulates ER homeostasis by limiting the accumulation of aberrant proteins that would otherwise trigger prolonged unfolded protein response signaling. By promoting efficient clearance of defective substrates, Synoviolin helps balance protein synthesis with folding capacity and prevents chronic ER stress. Synoviolin expression is broadly observed across tissues, reflecting the universal requirement for ER quality control in secretory and metabolically active cells. A Synoviolin antibody supports studies examining ubiquitin-dependent protein degradation and ER stress regulation.
Synoviolin has been implicated in controlling the stability of specific regulatory proteins involved in cell survival, inflammation, and metabolic signaling. Altered Synoviolin activity can influence cellular responses to stress by modulating degradation rates of ER-resident and ER-associated substrates. In experimental systems, changes in Synoviolin levels affect sensitivity to ER stressors and perturbations in protein folding demand, highlighting its role as a gatekeeper of ER proteostasis.
From a biological and disease-relevance perspective, Synoviolin has been studied in the context of inflammatory disease, fibrosis, and cancer biology, where dysregulated protein quality control contributes to pathogenesis. HRD1-mediated ERAD activity influences inflammatory signaling pathways and cell fate decisions under stress conditions. Understanding Synoviolin expression and regulation provides insight into how cells adapt to chronic ER stress and maintain homeostasis under pathological challenges.
At the molecular level, Synoviolin is encoded by the SYVN1 gene and produces a protein of approximately 617 amino acids. The protein contains multiple transmembrane domains anchoring it to the ER membrane and a cytosolic RING finger motif required for E3 ubiquitin ligase activity. Regulation of Synoviolin occurs through transcriptional control, protein interactions, and feedback from ER stress signaling pathways. A Synoviolin antibody supports research applications focused on ER-associated degradation, ubiquitin signaling, and cellular stress responses, with NSJ Bioreagents providing reagents intended for research use. -
UniProt
- Q86TM6
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途径
- ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling
抗原
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