Indian Hedgehog 抗体 (AA 227-360)
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Quick Overview for Indian Hedgehog 抗体 (AA 227-360) (ABIN8093262)
抗原
See all Indian Hedgehog (IHH) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 227-360
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原理
- IHH Antibody / Indian hedgehog protein
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human Indian hedgehog protein recombinant protein (amino acids D227-A360) was used as the immunogen for the IHH antibody.
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亚型
- IgG
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anti-Indian Hedgehog (IHH) (AA 203-411) antibody
IHH 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Indian Hedgehog (IHH) (AA 1-30), (N-Term) antibodyIHH 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB10375 unconjugated
anti-Indian Hedgehog (IHH) (N-Term) antibodyIHH 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, Cow, 山羊, 马, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Indian Hedgehog (IHH) antibodyIHH 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Indian Hedgehog (IHH) (AA 24-73) antibodyIHH 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 猴, Bat, 小鸡, Pig, 非洲爪蟾 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Indian Hedgehog (IHH) (AA 45-195) antibodyIHH 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Indian Hedgehog (IHH) antibodyIHH 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB4680 unconjugated Recombinant Antibody
anti-Indian Hedgehog (IHH) (AA 119-217) antibodyIHH 适用: 人 WB 宿主: 小鼠 Monoclonal 2G9 unconjugated
anti-Indian Hedgehog (IHH) (AA 161-260) antibodyIHH 适用: 人 IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Indian Hedgehog (IHH) (AA 1-30) antibodyIHH 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the IHH antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the IHH antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Indian Hedgehog (IHH)
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别名
- IHH
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背景
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IHH antibody targets Indian hedgehog protein, encoded by the IHH gene. Indian hedgehog protein is a secreted signaling molecule belonging to the hedgehog family and plays a central role in embryonic development and tissue patterning. IHH is synthesized as a precursor protein that undergoes autocatalytic cleavage to generate an active N-terminal signaling fragment responsible for pathway activation.
Functionally, Indian hedgehog protein regulates cell proliferation and differentiation through activation of the hedgehog signaling pathway. By interacting with Patched receptors and modulating downstream Gli transcription factors, IHH coordinates communication between neighboring cell populations. An IHH antibody supports studies focused on morphogen signaling and developmental regulation.
IHH expression is especially prominent in skeletal tissues, where it is produced by prehypertrophic chondrocytes during bone development. In this context, Indian hedgehog protein governs the balance between cartilage growth and maturation by coordinating feedback signaling with surrounding perichondrial cells. This spatially restricted expression highlights its importance in endochondral ossification.
From a disease-relevance perspective, dysregulation of Indian hedgehog protein signaling has been linked to skeletal abnormalities and growth plate disorders. Aberrant IHH pathway activity has also been examined in cancer and fibrotic disease, where reactivation of developmental signaling contributes to pathological tissue remodeling.
At the molecular level, Indian hedgehog protein undergoes lipid modification that influences secretion, signaling range, and gradient formation. These processing events can affect its apparent behavior in biochemical assays without altering the primary sequence. IHH antibody reagents support research applications focused on developmental biology and hedgehog pathway signaling, with NSJ Bioreagents providing reagents intended for research use. -
UniProt
- Q14623
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途径
- Hedgehog Signaling
抗原
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