Recombinant Cyclin A 抗体 (N-Term)
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Quick Overview for Recombinant Cyclin A 抗体 (N-Term) (ABIN8093106)
抗原
See all Cyclin A (CCNA2) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- N-Term
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原理
- CCNA2 Antibody / Cyclin A2
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免疫原
- Recombinant protein corresponding to the N-terminal fragment of cyclin A protein was used as the immunogen for the recombinant S phase cyclin/Cyclin A2 antibody.
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亚型
- IgG1, kappa
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anti-Cyclin A2 (CCNA2) antibody
KO Validated CCNA2 适用: 人 WB, IF, ICC, IHC (p), IP 宿主: 兔 Polyclonal unconjugated
anti-Cyclin A2 (CCNA2) (AA 105-233) antibodyCCNA2 适用: 人 WB, IHC, FACS, ELISA 宿主: 小鼠 Monoclonal 6B4D11 unconjugated
anti-Cyclin A2 (CCNA2) antibodyKD Validated CCNA2 适用: 人 WB, FACS, ICC, IF (p) 宿主: 兔 Monoclonal 23GB1875 unconjugated Recombinant Antibody
anti-Cyclin A2 (CCNA2) (AA 10-168) antibodyCCNA2 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin A2 (CCNA2) (AA 190-270) antibodyCCNA2 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cyclin A2 (CCNA2) (AA 51-84), (N-Term) antibodyCCNA2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB14617 unconjugated
anti-Cyclin A2 (CCNA2) (AA 375-431) antibodyCCNA2 适用: 人 WB, IHC (p), IF (p), IHC (fro), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Cyclin A2 (CCNA2) (AA 51-84) antibodyCCNA2 适用: 人 WB, IHC, FACS, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cyclin A2 (CCNA2) (C-Term) antibodyCCNA2 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Monoclonal BLR369N unconjugated Recombinant Antibody
anti-Cyclin A2 (CCNA2) (C-Term) antibodyCCNA2 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Monoclonal BLR369N unconjugated Recombinant Antibody
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应用备注
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1. Optimal dilution of the recombinant S phase cyclin/Cyclin A2 antibody should be determined by the researcher.
2. This S phase cyclin/Cyclin A2 antibody is recombinantly produced by expression in CHO cells. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- S phase cyclin/Cyclin A2 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- Cyclin A (CCNA2) (Cyclin A2 (CCNA2))
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别名
- CCNA2
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背景
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S phase cyclin Antibody recognizes Cyclin A2, also known as CCNA2 and Cyclin A, a key regulator of DNA replication and cell cycle progression. Cyclin A2 is a member of the cyclin family of cell cycle proteins and functions as a regulatory partner of cyclin-dependent kinases, particularly CDK2 during S phase and CDK1 during G2 phase. As the principal S phase cyclin, Cyclin A2 controls the initiation and progression of DNA synthesis and coordinates orderly transition toward mitosis. S phase cyclin Antibody is frequently described in the literature as Cyclin A2 antibody or CCNA2 antibody and is widely used in proliferation and oncology research.
Cyclin A2 expression is tightly cell cycle regulated and is largely confined to actively cycling cells. CCNA2 levels rise during S phase, where Cyclin A2-CDK2 complexes drive DNA replication, and remain elevated through G2 phase as Cyclin A2-CDK1 activity contributes to preparation for mitotic entry. In tissue sections, Cyclin A2 staining is typically observed in the nuclei of proliferating epithelial and tumor cells, while quiescent, differentiated, or resting cells show minimal expression. This nuclear localization pattern makes Cyclin A2 a useful marker of S phase activity and cellular proliferation.
Aberrant Cyclin A2 expression has been reported in numerous malignancies. Elevated CCNA2 levels are frequently associated with increased proliferative index, high-grade tumors, and aggressive tumor behavior in certain cancer types. Consequently, Cyclin A2 antibody staining is commonly evaluated in studies examining cell cycle dysregulation, tumor growth, and response to therapeutic interventions. CCNA2 is also investigated in developmental and regenerative biology contexts where controlled cell division is required.
At the molecular level, Cyclin A2 acts as a checkpoint regulator that integrates signals controlling DNA replication and mitotic entry through precise modulation of cyclin-dependent kinase activity. Its essential role in S phase progression and G2-M transition makes S phase cyclin Antibody a valuable tool for assessing proliferative status and studying mechanisms of cell cycle control. -
UniProt
- P20248
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途径
- PI3K-Akt Signaling, Cell Division Cycle, AMPK Signaling, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA
抗原
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