CGRP 抗体
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Quick Overview for CGRP 抗体 (ABIN8065542)
抗原
See all CGRP (CALCA) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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原理
- Anti-Alpha-Calcitonin Gene-Related Peptide (alpha-CGRP) Antibody
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特异性
- ABIN8065542 binds human α-CGRP. Based on inhibition ELISA, ABIN8065542 shows full cross-reactivity with rat α-CGRP and about 50 % cross-reactivity with human b-CGRP. There is no cross-reaction with human amylin. The epitope lies within residues 1-18 of human α-CGRP.
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预测反应
- Human,Rat
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纯化方法
- Protein A or Protein G purified
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免疫原
- Synthetic human alpha-CGRP
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亚型
- IgG1, kappa
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anti-Calcitonin-Related Polypeptide alpha (CALCA) (AA 1-141) antibody
CALCA 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin-Related Polypeptide alpha (CALCA) (AA 1-130) antibodyCALCA 适用: 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin-Related Polypeptide alpha (CALCA) (AA 52-141) antibodyCALCA 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 4B10 unconjugated
anti-Calcitonin-Related Polypeptide alpha (CALCA) (C-Term) antibodyCALCA 适用: 大鼠, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin-Related Polypeptide alpha (CALCA) (AA 65-130) antibodyCALCA 适用: 人 WB, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin-Related Polypeptide alpha (CALCA) antibodyCALCA 适用: 小鼠 WB, IHC 宿主: 兔 Monoclonal BLR159J unconjugated Recombinant Antibody
anti-Calcitonin-Related Polypeptide alpha (CALCA) (AA 56-83) antibodyCALCA 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB19409 unconjugated
anti-Calcitonin-Related Polypeptide alpha (CALCA) (AA 1-134) antibodyCALCA 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin-Related Polypeptide alpha (CALCA) (AA 75-125) antibodyCALCA 适用: 人, 小鼠 WB, IP 宿主: 兔 Monoclonal BLR169J unconjugated Recombinant Antibody
anti-Calcitonin-Related Polypeptide alpha (CALCA) antibodyCALCA 适用: 大鼠 ELISA, ICC 宿主: 小鼠 Monoclonal 4901 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- 2-8°C without exposure to light
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有效期
- 24 months
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- CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))
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别名
- Alpha-Calcitonin Gene-Related Peptide
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背景
- CALCA, CALC1, CGRP, CGRP-I, CGRP-alpha, CGRP1, CT, KC, PCT, calcitonin, calcitonin gene-related peptide 1, alpha-type CGRP, calcitonin 1, calcitonin gene-related peptide I, calcitonin/calcitonin-related polypeptide, alpha, katacalcin,CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex (PubMed:1318039, PubMed:33602864, PubMed:9620797). Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role (PubMed:3492492). It also elevates platelet cAMP (PubMed:1318039). CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex (PubMed:38603770). {ECO:0000269|PubMed:1318039, ECO:0000269|PubMed:33602864, ECO:0000269|PubMed:3492492, ECO:0000269|PubMed:38603770, ECO:0000269|PubMed:9620797}.,CALCA,Calcitonin gene-related peptide is a 37 amino acid vasoactive neuropeptide (MW 3789) widely expressed throughout the central and peripheral nervous system. CGRP has potent vasodilatory effects probably serving as a regulator of regional blood flow, In addition to a variety of other cellular effects.
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分子量
- 11 kDa (pro-CGRP), 5 kDa (active)
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基因ID
- 796
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UniProt
- P06881
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途径
- Hormone Activity, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development, Feeding Behaviour
抗原
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