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CGRP 抗体

CALCA 适用: 大鼠 ELISA, WB, IHC, IP, FM 宿主: 小鼠 Monoclonal 4901 unconjugated
产品编号 ABIN6658144
发货至: 中国
  • 抗原 See all CGRP (CALCA) 抗体
    CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))
    适用
    • 67
    • 38
    • 12
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    大鼠
    宿主
    • 60
    • 17
    • 6
    • 2
    • 2
    • 1
    小鼠
    克隆类型
    • 70
    • 17
    单克隆
    标记
    • 58
    • 7
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CGRP antibody is un-conjugated
    应用范围
    • 54
    • 38
    • 28
    • 13
    • 13
    • 11
    • 10
    • 8
    • 8
    • 7
    • 6
    • 5
    • 3
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    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Fluorescence Microscopy (FM)
    交叉反应
    人, 大鼠
    纯化方法
    Anti-CGRP Monoclonal Antibody is directed against rat CGRP protein. The antibody was purified from concentrated tissue culture supernate by Protein G chromatography. This antibody is specific for human and rat CGRP protein. A BLAST analysis was used to suggest cross-reactivity with CGRP from most mammalian sources based on very high homology with the immunizing sequence. Calcitonin Gene Related Peptide antibody also recognizes rat beta-CGRP and human alpha-CGRP (10-fold less sensitivity compared to rat alpha-CGRP).
    免疫原

    Immunogen: Anti-CGRP Monoclonal Antibody was produced by repeated immunizations with purified rat alpha-CGRP.

    Immunogen Type: Recombinant Protein

    克隆位点
    4901
    亚型
    IgG2a
    Top Product
    Discover our top product CALCA Primary Antibody
  • 应用备注

    Immunohistochemistry Dilution: 1:50-1:100

    Application Note: Anti-Calcitonin Gene Related Peptide antibody is suitable for use in ELISA and ICC. This product is not recommended for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Suggested positive controls are dorsal root ganglia, pancreas and gut.

    Immunoprecipitation Dilution: 1:50-1:100

    ELISA Dilution: 1:5,000

    Western Blot Dilution: not recommended

    IF Microscopy Dilution: 1:50-1:100

    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液

    Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

    Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

    储存条件
    4 °C,-20 °C
    储存方法
    Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
  • Dhandapani, Arokiaraj, Taberner, Pacifico, Raja, Nocchi, Portulano, Franciosa, Maffei, Hussain, de Castro Reis, Reymond, Perlas, Garcovich, Barth, Johnsson, Lechner, Heppenstall: "Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons." in: Nature communications, Vol. 9, Issue 1, pp. 1640, (2019) (PubMed).

  • 抗原
    CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))
    别名
    Calcitonin Gene Related Peptide (CGRP) (CALCA 产品)
    别名
    CALC1 antibody, CGRP antibody, CGRP-I antibody, CGRP1 antibody, CT antibody, KC antibody, CALC antibody, CALCA antibody, CALC3 antibody, ci-ct antibody, calca antibody, CA antibody, CGRP-1 antibody, Calc antibody, Calc1 antibody, Cgrp antibody, Ct antibody, Ctn antibody, calcitonin antibody, CAL6 antibody, Cal1 antibody, RATCAL6 antibody, CGRPI antibody, calc antibody, cgrp antibody, zgc:92886 antibody, calcitonin related polypeptide alpha antibody, calcitonin related polypeptide beta antibody, calcitonin-related polypeptide alpha antibody, calcitonin antibody, calcitonin/calcitonin-related polypeptide, alpha antibody, calcitonin-related polypeptide beta antibody, calcitonin gene-related peptide 2 antibody, CALCA antibody, CALCB antibody, ci-ct antibody, calca antibody, Calca antibody, LOC100008771 antibody
    背景

    Synonyms: Alpha-type CGRP, Calcitonin gene-related peptide I

    Background: CGRP antibody recognizes Calcitonin Gene Related Peptide or CGRP which is a 37 amino acid peptide and is the most potent endogenous vasodilator currently known. CGRP is primarily produced in nervous tissue, however, its receptors are expressed throughout the body. CGRP is also strongly implicated in the vasodilatory effect of endogenous cannabinoid anandamide in the brain. This effect was found to be antagonized by capsazepine. CGRP is also currently a major target of research in regards to factors effecting the onset of migraine headaches. CGRP antibodies have been used successfully in immunoneutralization. Anti-CGRP antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

    Gene Name: CALCA

    基因ID
    24241
    NCBI登录号
    NP_001029128
    UniProt
    P01256
    途径
    Hormone Activity, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development, Feeding Behaviour
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