C1S 抗体
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北京 101111
Quick Overview for C1S 抗体 (ABIN8065539)
抗原
See all C1S 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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原理
- Anti-Pro/Actived Complement C1s Antibody
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特异性
- ABS 002-49 is specific for C1s proenzyme and activated free C1s and C1s in complex with C1 inhibitor. Epitope differs from that of ABS 002-09.
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预测反应
- Human
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纯化方法
- Protein A or Protein G purified
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免疫原
- Human plasma C1s Proenzyme
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亚型
- IgG1, kappa
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anti-Complement Component 1, S Subcomponent (C1S) (AA 1-688) antibody
C1S 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, S Subcomponent (C1S) antibodyC1S 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, S Subcomponent (C1S) antibodyC1S 适用: 人 WB, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, S Subcomponent (C1S) (AA 1-688) antibodyC1S 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Complement Component 1, S Subcomponent (C1S) antibodyC1S 适用: 人 IHC, ELISA, IHC (p) 宿主: 山羊 Polyclonal unconjugated
anti-Complement Component 1, S Subcomponent (C1S) antibodyC1S 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 2F5 unconjugated
anti-Complement Component 1, S Subcomponent (C1S) (C-Term) antibodyC1S 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, S Subcomponent (C1S) (AA 438-685) antibodyC1S 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, S Subcomponent (C1S) antibodyC1S 适用: 人, 大鼠, 小鼠, 猴 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2A8 unconjugated
anti-Complement Component 1, S Subcomponent (C1S) (cleaved), (Internal Region) antibodyC1S 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- 2-8°C without exposure to light
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有效期
- 24 months
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- C1S (Complement Component 1, S Subcomponent (C1S))
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别名
- Pro/Actived Complement C1s
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背景
- C1S, EDSPD2, complement C1s subcomponent, C1 esterase, basic proline-rich peptide IB-1, complement component 1 subcomponent s, complement component 1, s subcomponent,Component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:11445589, PubMed:16169853, PubMed:417728, PubMed:467643, PubMed:6271784, PubMed:6282646, PubMed:6319179, PubMed:70787, PubMed:9422791). C1S is activated following association of the C1 complex with immunoglobulins (IgG or IgM) complexed with antigens to form antigen-antibody complexes on the surface of pathogens (PubMed:34155115). C1S is cleaved and activated by C1R to generate C1s subcomponent heavy and light chains (PubMed:11445589, PubMed:6271784). C1s subcomponent light chain then cleaves and activates C2 and C4, the next components of the classical complement pathway (PubMed:16169853, PubMed:467643, PubMed:6282646, PubMed:6319179, PubMed:6906228, PubMed:70787, PubMed:9422791). {ECO:0000269|PubMed:11445589, ECO:0000269|PubMed:16169853, ECO:0000269|PubMed:34155115, ECO:0000269|PubMed:417728, ECO:0000269|PubMed:467643, ECO:0000269|PubMed:6271784, ECO:0000269|PubMed:6282646, ECO:0000269|PubMed:6319179, ECO:0000269|PubMed:6906228, ECO:0000269|PubMed:70787, ECO:0000269|PubMed:9422791}., [Complement C1s subcomponent light chain]: Serine protease component of the complement C1 complex, which catalyzes cleavage and activation of C2 and C4, the next components of the classical complement pathway (PubMed:16169853, PubMed:22949645, PubMed:417728, PubMed:467643, PubMed:6282646, PubMed:6319179, PubMed:70787, PubMed:9422791). Also able to cleave C1 inhibitor (SERPING1) in vitro, additional evidence is however required to confirm this result in vivo (PubMed:16169853). Also cleaves IGFBP5 and thereby inhibits the trophic effects of IGF1 (PubMed:18930415). {ECO:0000269|PubMed:16169853, ECO:0000269|PubMed:18930415, ECO:0000269|PubMed:22949645, ECO:0000269|PubMed:417728, ECO:0000269|PubMed:467643, ECO:0000269|PubMed:6282646, ECO:0000269|PubMed:6319179, ECO:0000269|PubMed:70787, ECO:0000269|PubMed:9422791}.,C1S,C1s proenzyme is a 79.8 kDa glycoprotein produced primarily by hepatocytes but also by other cells. The proenzyme is produced as a single-chain polypeptide of 688 aa. Upon activation the peptide is cleaved between R437 and I438 giving the activated enzyme consisting of two disulfide-linked chains, A chain (52.2 kDa) and B chain (27.7 kDa). The Ca-dependent catalytic subunit of the C1 complex (C1q, C1r, C1s) comprises of two C1s and two C1r molecules and this serine protease tetramer is responsible for the initial steps in the classical complement pathway, cleavage of C4 and C2.
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分子量
- Pro-enzyme C1s (pro-C1s) appears as a single-chain polypeptide around 80 kDa. Upon activation, it is cleaved into two disulfide-linked chains: a ~57 kDa A-chain and and 27 kDa B-chain).
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基因ID
- 716
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UniProt
- P09871
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途径
- Complement System
抗原
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