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AXL 抗体 (AA 151-250)

Name: AXL 抗体 (AA 151-250)
SKU: ABIN756022
Availability: OutOfStock

This anti-AXL antibody is a 兔多克隆 antibody detecting AXL in WB, ELISA, IHC (p), IF (cc), IF (p) 和 IHC (fro). Suitable for 人, 小鼠和大鼠. This Primary Antibody has been cited in 3+ publications.

Formalin-fixed and paraffin embedded mouse embryo labeled with Rabbit Anti AXL/UFO Polyclonal Antibody, Unconjugated (ABIN756022) at 1:200 followed by conjugation to the secondary antibody and DAB staining (AXL 抗体 (AA 151-250))

IHC

Formalin-fixed and paraffin embedded human colon carcinoma labeled with Rabbit Anti AXL/UFO Polyclonal Antibody, Unconjugated (ABIN756022) at 1:200 followed by conjugation to the secondary antibody and DAB staining (AXL 抗体 (AA 151-250))

IHC

2 images

(3 references)

产品编号 ABIN756022

发货至: 中国

Quick Overview for AXL 抗体 (AA 151-250) (ABIN756022)

抗原

See all AXL 抗体

AXL (AXL Receptor tyrosine Kinase (AXL))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This AXL antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Discover our top product AXL Primary Antibody

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AA 151-250

交叉反应

人, 小鼠, 大鼠

预测反应

Dog,Horse,Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human AXL

亚型

IgG
anti-AXL Receptor tyrosine Kinase (AXL) (AA 30-140) antibody
AXL 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 6C8 unconjugated

anti-AXL Receptor tyrosine Kinase (AXL) antibody
AXL 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated

anti-AXL Receptor tyrosine Kinase (AXL) (AA 13-44) antibody
AXL 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated

anti-AXL Receptor tyrosine Kinase (AXL) (AA 312-447) antibody
AXL 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-AXL Receptor tyrosine Kinase (AXL) (AA 21-202) antibody
AXL 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-AXL Receptor tyrosine Kinase (AXL) (AA 1-894) antibody
AXL 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-AXL Receptor tyrosine Kinase (AXL) antibody
AXL 适用: 人 ELISA, ICC 宿主: 小鼠 Monoclonal 7E10 unconjugated

anti-AXL Receptor tyrosine Kinase (AXL) (C-Term) antibody
KO Validated AXL 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-AXL Receptor tyrosine Kinase (AXL) (AA 787-885) antibody
AXL 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2C10 unconjugated

anti-AXL Receptor tyrosine Kinase (AXL) (AA 466-530) antibody
AXL 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1B3A2 unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Novoyatleva, Rai, Kojonazarov, Veeroju, Ben-Batalla, Caruso, Shihan, Presser, Götz, Lepper, Herpel, Manaud, Perros, Gall, Ghofrani, Weissmann, Grimminger, Wharton, Wilkins, Upton, Loges, Morrell et al.: "Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2. ..." in: Communications biology, Vol. 4, Issue 1, pp. 1002, (2021) (PubMed).

Liu, Lu, Zhang, Zhu, Dong, Guo, Li, Nan, Yu, Zhong, Huang: "Amlexanox, a selective inhibitor of IKBKE, generates anti-tumoral effects by disrupting the Hippo pathway in human glioblastoma cell lines." in: Cell death & disease, Vol. 8, Issue 8, pp. e3022, (2018) (PubMed).
抗原

AXL (AXL Receptor tyrosine Kinase (AXL))

别名

AXL

背景

Synonyms: UFO, JTK11, Tyrosine-protein kinase receptor UFO, AXL oncogene, AXL
Background: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3, but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor.

基因ID

558

UniProt

P30530

途径

RTK signaling, Cellular Response to Molecule of Bacterial Origin