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PTBP1 抗体 (AA 1-504) (Biotin)

The 兔 多克隆 anti-PTBP1 antibody is suitable to detect PTBP1 in samples from 人, 小鼠 和 大鼠. It has been validated for WB, IHC 和 ELISA.
产品编号 ABIN8024397
发货至: 中国
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Quick Overview for PTBP1 抗体 (AA 1-504) (Biotin) (ABIN8024397)

抗原

See all PTBP1 抗体
PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))

适用

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人, 小鼠, 大鼠

宿主

  • 81
  • 19
  • 1

克隆类型

  • 51
  • 50
多克隆

标记

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This PTBP1 antibody is conjugated to Biotin

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), ELISA
  • 抗原表位

    • 25
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    • 1
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    • 1
    AA 1-504

    原理

    Anti-PTBP1 Antibody Biotin Conjugated

    特异性

    No cross reactivity with other proteins.

    交叉反应 (详细)

    No cross-reactivity with other proteins.

    纯化方法

    Immunogen affinity purified.

    免疫原

    E.coli-derived human PTBP1 recombinant protein (Position: M1-A504).

    亚型

    IgG
  • 应用备注

    Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

    有效期

    12 months
  • 抗原

    PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))

    别名

    PTBP1

    背景

    Background: Polypyrimidine tract-binding protein 1 is a protein that in humans is encoded by the PTBP1 gene. It is mapped to 19p13.3. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

    Gene Full Name: polypyrimidine tract binding protein 1

    基因ID

    5725

    UniProt

    P26599

    途径

    Regulation of Muscle Cell Differentiation
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