POLH 抗体 (AA 157-361) (Fluoro594)
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北京 101111
Quick Overview for POLH 抗体 (AA 157-361) (Fluoro594) (ABIN8024136)
抗原
See all POLH 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 157-361
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原理
- Anti-DNA polymerase eta/POLH Antibody Fluoro594 Conjugated
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特异性
- No cross reactivity with other proteins.
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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预测反应
- Human POLH shares 93.6% amino acid (aa) sequence identity with mouse POLH.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human POLH recombinant protein (Position: A157-R361). Human POLH shares 93.6% amino acid (aa) sequence identity with mouse POLH.
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亚型
- IgG
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anti-Polymerase (DNA Directed), eta (POLH) antibody
POLH 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), eta (POLH) antibodyPOLH 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), eta (POLH) (AA 408-609) antibodyPOLH 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), eta (POLH) (AA 20-320) antibodyPOLH 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), eta (POLH) (AA 1-713) antibodyPOLH 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Polymerase (DNA Directed), eta (POLH) (AA 1-713) antibodyPOLH 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), eta (POLH) (Internal Region) antibodyPOLH 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), eta (POLH) (AA 690-713) antibodyPOLH 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- POLH (Polymerase (DNA Directed), eta (POLH))
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别名
- POLH
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背景
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Background: DNA polymerase eta (Pol η), is a protein that in humans is encoded by the POLH gene. This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-ed polymerases. However, it accurately replicates UV-damaged DNA, when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.
Gene Full Name: DNA polymerase eta
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基因ID
- 5429
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UniProt
- Q9Y253
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途径
- DNA Damage Repair
抗原
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