POLB 抗体 (AA 122-335) (PE)
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北京 101111
Quick Overview for POLB 抗体 (AA 122-335) (PE) (ABIN8024095)
抗原
See all POLB 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 122-335
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原理
- Anti-DNA Polymerase beta/POLB Antibody PE Conjugated
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特异性
- No cross reactivity with other proteins.
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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预测反应
- Human POLB shares 95.3%,94.9% amino acid (aa) sequence identity with mouse,rat POLB,respectively.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human POLB recombinant protein (Position: L122-E335). Human POLB shares 95.3% and 94.9% amino acid (aa) sequence identity with mouse and rat POLB, respectively.
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亚型
- IgG
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anti-Polymerase (DNA Directed), beta (POLB) (AA 1-335) antibody
POLB 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), beta (POLB) (AA 1-335) antibodyPOLB 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Polymerase (DNA Directed), beta (POLB) (C-Term) antibodyPOLB 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), beta (POLB) antibodyKD Validated POLB 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 24GB1475 unconjugated Recombinant Antibody
anti-Polymerase (DNA Directed), beta (POLB) (AA 1-300) antibodyPOLB 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), beta (POLB) antibodyPOLB 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Polymerase (DNA Directed), beta (POLB) (AA 55-160) antibodyPOLB 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), beta (POLB) (C-Term) antibodyPOLB 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), beta (POLB) (C-Term) antibodyPOLB 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), beta (POLB) (AA 224-333) antibodyPOLB 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- POLB (Polymerase (DNA Directed), beta (POLB))
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别名
- POLB
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背景
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Background: Polymerase (DNA ed), beta, also known as POLB, is an enzyme that, in humans, is encoded by the POLB gene. It is localized on 8p11.2. The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. It is found that a truncated POLB is expressed in primary colorectal tumors and inhibits the normal repair function of wildtype POLB. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. Additionally, human POLB forms a complex with and is methylated by PRMT6. In vitro, methylated POLB possesses significantly higher DNA polymerase activity when compared to that of unmodified enzyme. The increase in DNA polymerase activity upon methylation is due to the enhanced DNA binding and processivity of POLB.
Gene Full Name: DNA polymerase beta
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基因ID
- 5423
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UniProt
- P06746
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途径
- DNA Damage Repair
抗原
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