MSH2 抗体 (AA 337-583) (FITC)
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Quick Overview for MSH2 抗体 (AA 337-583) (FITC) (ABIN8010580)
抗原
See all MSH2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 337-583
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原理
- Anti-MSH2 Antibody FITC Conjugated
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特异性
- No cross reactivity with other proteins.
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交叉反应 (详细)
- No cross-reactivity with other proteins
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预测反应
- Human MSH2 shares 94%,93% amino acid (aa) sequence identity with mouse,rat MSH2,respectively.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human MSH2 recombinant protein (Position: Q337-N583). Human MSH2 shares 94% and 93% amino acid (aa) sequence identity with mouse and rat MSH2, respectively.
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亚型
- IgG
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- MSH2 (Mismatch Repair Protein 2 (MSH2))
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别名
- MSH2
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背景
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Background: DNA mismatch repair protein Msh2, also known as MutS protein homolog 2 or MSH2, is a protein that in humans is encoded by the MSH2 gene, which is located on chromosome 2. MSH2 is a tumor suppressor gene and more specifically a caretaker gene that codes for a DNA mismatch repair (MMR) protein, MSH2 which forms aheterodimer with MSH6 to make the human MutSα mismatch repair complex. It also dimerizes with MSH3 to form the MutSβ DNA repair complex. MSH2 is involved in many different forms of DNA repair, including transcription-coupled repair, homologous recombination, and base excision repair. It has been found that MSH2 may also be a coactivator of ESR1-dependent gene expression.
Gene Full Name: mutS homolog 2
Sequence Similarities: Belongs to the DNA mismatch repair MutS family.
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基因ID
- 4436
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UniProt
- P43246
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途径
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
抗原
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