MCAM 抗体 (AA 59-401) (Fluoro647)
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Quick Overview for MCAM 抗体 (AA 59-401) (Fluoro647) (ABIN8008933)
抗原
See all MCAM 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 59-401
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原理
- Anti-CD146/MCAM Antibody (monoclonal, 2H12) Fluoro647 Conjugated
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特异性
- No cross reactivity with other proteins.
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交叉反应 (详细)
- No cross-reactivity with other proteins.
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预测反应
- Human CD146 shares 73% amino acid (aa) sequence identity with both mouse,rat CD146.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human CD146 recombinant protein (Position: H59-A401). Human CD146 shares 73% amino acid (aa) sequence identity with both mouse and rat CD146.
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亚型
- IgG1
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- MCAM (Melanoma Cell Adhesion Molecule (MCAM))
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别名
- MCAM
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背景
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Background: CD146 (cluster of differentiation 146), also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113 kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. MCAM, a member of the immunoglobulin superfamily, is homologous to several cell adhesion molecules and is associated with tumor progression and the development of metastasis in human malignant melanoma. By radiation hybrid analysis, this gene is mapped to chromosome 11q23.3. MCAM has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. MCAM has been seen as a marker for mesenchymal stem cells isolated from multiple adult and fetal organs, and its expression may be linked to multipotency mesenchymal stem cells with greater differentiation potential express higher levels of MCAM on the cell surface.
Gene Full Name: melanoma cell adhesion molecule
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基因ID
- 4162
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UniProt
- P43121
抗原
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