IL-18 抗体 (AA 36-192) (Biotin)
Our Local Distributor
北京 101111
Quick Overview for IL-18 抗体 (AA 36-192) (Biotin) (ABIN8002079)
抗原
See all IL-18 (IL18) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 36-192
-
原理
- Anti-IL18 Antibody Biotin Conjugated
-
特异性
- No cross reactivity with other proteins.
-
交叉反应 (详细)
- No cross-reactivity with other proteins
-
预测反应
- Mouse IL-18 shares 66%,91% amino acid (aa) sequence identity with human,rat IL-18,respectively.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E.coli-derived mouse IL-18 recombinant protein (Position: N36-S192). Mouse IL-18 shares 66% and 91% amino acid (aa) sequence identity with human and rat IL-18, respectively.
-
亚型
- IgG
-
-
-
-
应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
-
有效期
- 12 months
-
-
- IL-18 (IL18) (Interleukin 18 (IL18))
-
别名
- IL18
-
背景
-
Background: < a href=https://www.bosterbio.com/anti-il-18-antibody-pa1342-boster.html style=color:#EA8D28>Interleukin-18, also known as IL18, is a protein which in humans is encoded by the IL18 gene. IL-18 is a cytokine produced by macrophages and other cells that belongs to the IL-1 superfamily. It is mapped to 11q22.2-q22.3. IL-18 works by binding to the interleukin-18 receptor, and together with IL-12, it induces cell-mediated immunity following infection with microbial products like lipopolysaccharide (LPS). After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-γ (IFN-γ) or type II interferon that plays an important role in activating the macrophages or other cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production in B cells.
Gene Full Name: interleukin 18
Sequence Similarities: Belongs to the IL-15/IL-21 family.
-
基因ID
- 16173
-
UniProt
- P70380
-
途径
- Cellular Response to Molecule of Bacterial Origin, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome
抗原
-