IGFBP5 抗体 (AA 60-272) (Cy3)
Our Local Distributor
北京 101111
Quick Overview for IGFBP5 抗体 (AA 60-272) (Cy3) (ABIN8000221)
抗原
See all IGFBP5 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 60-272
-
原理
- Anti-IGFBP5 Antibody Cy3 Conjugated
-
特异性
- No cross reactivity with other proteins.
-
交叉反应 （详细）
- No cross-reactivity with other proteins.
-
预测反应
- coli-derived human IGFBP5 recombinant protein (Position: A60-E272). Human IGFBP5 shares 96.7%,96.2% amino acid (aa) sequence identity with mouse,rat IGFBP5,respectively.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E. coli-derived human IGFBP5 recombinant protein (Position: A60-E272). Human IGFBP5 shares 96.7% and 96.2% amino acid (aa) sequence identity with mouse and rat IGFBP5, respectively.
-
亚型
- IgG
-
-
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 68-167) antibody
IGFBP5 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 25-271) antibodyIGFBP5 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) antibodyIGFBP5 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 101-200) antibodyIGFBP5 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 87-121) antibodyIGFBP5 适用: 人 WB 宿主: 兔 Polyclonal RB54635 unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 27-248) antibodyIGFBP5 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C2 unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 27-248) antibodyIGFBP5 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 1-272) antibodyIGFBP5 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Insulin-Like Growth Factor Binding Protein 5 (IGFBP5) (AA 111-160) antibodyIGFBP5 适用: 人, 小鼠, 大鼠, Cow, 犬, Pig, 兔, 绵羊, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Flow Cytometry, 1-3 μg/1x106 cells
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
-
有效期
- 12 months
-
-
- IGFBP5 (Insulin-Like Growth Factor Binding Protein 5 (IGFBP5))
-
别名
- IGFBP5
-
背景
-
Background: Insulin-like growth factor-binding protein 5 is a protein that in humans is encoded by the IGFBP5 gene. The expression of IGFBP5 by stable transfection and adenovirus-mediated infection is inhibitory to growth in 2 human breast cancer cell lines. IGFBP5 expression leads to G2/M cell cycle arrest and apoptosis. Stable expression of IGFBP5 in the breast cancer cell lines also inhibits the formation and growth of tumors following injection in athymic mice. It is concluded that IGFBP5 is a growth inhibitor and proapoptotic agent in breast cancer cells. Additionally, IGFBP-5 is expressed by fibroblasts, myoblasts and osteoblasts, making it the predominant IGFBP found in bone extracts. It has a strong affinity for hydroxyapatite, allowing it to bind to bone cells. When bound to extracellular matrix, IGFBP-5 is protected from proteolysis and potentiates IGF activity, but when it is soluble, IGFBP-5 is cleaved to a biologically inactive 21 kDa fragment (1, 2).
Gene Full Name: insulin like growth factor binding protein 5
-
基因ID
- 3488
-
UniProt
- P24593
-
途径
- WNT signaling, Carbohydrate Homeostasis, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Growth Factor Binding
抗原
-
