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BTK 抗体 (AA 581-659)

Name: BTK 抗体 (AA 581-659)
SKU: ABIN750098
Availability: OutOfStock

This anti-BTK antibody is a 兔多克隆 antibody detecting BTK in WB, ELISA, IF (cc), IF (p) 和 IHC (fro). Suitable for 大鼠. This Primary Antibody has been cited in 1 publication.

(1 reference)

产品编号 ABIN750098

发货至: 中国

Datasheet as PDF

Quick Overview for BTK 抗体 (AA 581-659) (ABIN750098)

抗原

See all BTK 抗体

BTK (Bruton Agammaglobulinemia tyrosine Kinase (BTK))

适用

大鼠

宿主

兔

克隆类型

多克隆

标记

This BTK antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Discover our top product BTK Primary Antibody

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AA 581-659

交叉反应

大鼠

预测反应

Human,Mouse,Dog,Cow,Pig,Horse,Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human BTK

亚型

IgG
anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (AA 30-240) antibody
BTK 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) antibody
BTK 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated

anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (AA 209-239) antibody
BTK 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (AA 27-55) antibody
BTK 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (pSer180) antibody
BTK 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (AA 254-443) antibody
BTK 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (AA 91-387) antibody
BTK 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (Internal Region) antibody
BTK 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (C-Term) antibody
BTK 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) antibody
BTK 适用: 人, 猴 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 7F12H4 unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Liu, Zhang, Han, Wang, Liu, Zhang, Zhou, Xiang: "Inhibition of BTK protects lungs from trauma-hemorrhagic shock-induced injury in rats." in: Molecular medicine reports, Vol. 16, Issue 1, pp. 192-200, (2017) (PubMed).
抗原

BTK (Bruton Agammaglobulinemia tyrosine Kinase (BTK))

别名

BTK

背景

Synonyms: Agammaglobulinaemia tyrosine kinase, AGMX 1, AGMX1, AT, ATK, B cell progenitor kinase, B-cell progenitor kinase, BPK, Bruton agammaglobulinemia tyrosine kinase, Bruton tyrosine kinase, Bruton?s Tyrosine Kinase, Btk, BTK_HUMAN, IMD 1, IMD1, MGC126261, MGC126262, OTTHUMP00000063593, PSCTK 1, PSCTK1, Tyrosine protein kinase BTK, Tyrosine-protein kinase BTK, XLA.
Background: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.

基因ID

695

途径

Fc-epsilon Receptor Signaling Pathway, Hormone Transport, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, BCR Signaling