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HSPD1 抗体 (AA 260-496)

Name: HSPD1 抗体 (AA 260-496)
SKU: ABIN7996274
Availability: OutOfStock

The 小鼠单克隆 anti-HSPD1 antibody (Clone 6G2) (ABIN7996274) specifically detects HSPD1 in WB, IHC, IF, FACS 和 ICC. The antibody is reactive with 人, 小鼠和大鼠 samples.

产品编号 ABIN7996274

发货至: 中国

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中国
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Quick Overview for HSPD1 抗体 (AA 260-496) (ABIN7996274)

抗原

See all HSPD1 抗体

HSPD1 (Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1))

适用

人, 小鼠, 大鼠

宿主

小鼠

克隆类型

单克隆

标记

This HSPD1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

质量等级

Carrier-free

克隆位点

6G2

Discover our top product HSPD1 Primary Antibody

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AA 260-496

原理

Anti-Hsp60/HSPD1 Antibody (monoclonal, 6G2)

特异性

No cross reactivity with other proteins.

交叉反应（详细）

No cross-reactivity with other proteins.

预测反应

Human Hsp60 shares 97% amino acid (aa) sequence identity with both mouse,rat Hsp60.

产品特性

Anti-Hsp60/HSPD1 Antibody.(monoclonal, 6G2)-3. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

纯化方法

Immunogen affinity purified.

免疫原

E.coli-derived human Hsp60/HSPD1 recombinant protein (Position: A260-Q496). Human Hsp60 shares 97% amino acid (aa) sequence identity with both mouse and rat Hsp60.

亚型

IgG1
anti-Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1) (AA 501-573) antibody
HSPD1 适用: 人, 小鼠, 大鼠, Pig WB, ELISA, IHC (p), IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated

anti-Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1) antibody
HSPD1 适用: 人 WB, IHC, FACS, IP, ELISA 宿主: 小鼠 Monoclonal LK1 unconjugated

anti-Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1) antibody
HSPD1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 3G8 unconjugated

anti-Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1) (AA 27-240) antibody
HSPD1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1) (AA 1-573) antibody
HSPD1 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1) (AA 316-573) antibody
HSPD1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1) (AA 172-343) antibody
HSPD1 适用: 人 WB, IHC, FACS, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1) (AA 1-573) antibody
HSPD1 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1) antibody
HSPD1 适用: 人, 小鼠, 大鼠, 小鸡, 猴, 犬, Hamster, Cow, 兔, Pig, 绵羊, Drosophila melanogaster, 非洲爪蟾 WB, IHC, IF, FACS 宿主: 小鼠 Monoclonal LK1 unconjugated

anti-Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1) antibody
HSPD1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, EM 宿主: 兔 Polyclonal unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL Immunocytochemistry/Immunofluorescence, 5 μg/mL Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

有效期

12 months
抗原

HSPD1 (Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1))

别名

HSPD1

背景

Background: HSP60 is a member of the chaperonin class of protein factors, which include the Escherichia coli groEL protein and the Rubisco subunit-binding protein of chloroplasts. It acts as a costimulator of human regulatory CD4-positive/CD25 -positive T cells, which inhibit lymphoproliferation and IFNG and TNF secretion by CD4-positive and CD8-positive T cells. HSP60 enhances Treg activity via TLR2, leading to activation of an intracellular signaling cascade that included p38, as well as inhibition of ERK phosphorylation. Suppression of target T cells is mediated by both cell-to-cell contact and by secretion of TGFB and IL10, and it leads to downregulation of ERK, NFKB, and TBET expression. The self-molecule HSP60 can downregulate adaptive immune responses by upregulating Tregs through TLR2 signaling.
Gene Full Name: heat shock protein family D (Hsp60) member 1

分子量

60 kDa

基因ID

3329

UniProt

P10809

途径

Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity