DDR1 抗体 (AA 341-909) (PE)
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Quick Overview for DDR1 抗体 (AA 341-909) (PE) (ABIN7985558)
抗原
See all DDR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 341-909
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原理
- Anti-MCK10/NEP/DDR1 Antibody PE Conjugated
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特异性
- No cross reactivity with other proteins.
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交叉反应 (详细)
- No cross-reactivity with other proteins.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human MCK10/NEP/DDR1 recombinant protein (Position: R341-A909).
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亚型
- IgG
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))
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别名
- DDR1
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背景
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Background: DDR1 (Discoidin domain receptor family, member 1) also known as NEP, EDDR1, NTRK4, TRKE, DDR, CAK or RTK6, is a human gene. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen.This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain.The DDR1 gene is mapped on 6p21.33. The fibrillar collagens and immobilized collagen activatedDDR1receptor phosphorylation after prolonged treatment. Bhatt et al. (2000)showed thatDdr1was highly expressed in the cerebellum of developing and adult mouse brain, and that bothDdr1and collagen IV were highly expressed in the pial layer of the cerebellar cortex.Cocultures of collagen I- and IV-expressing mouse pial cells withDdr1-expressing granule cells resulted in granule cell neurite extension. Inhibition of collagen-Ddr1signaling reduced granule cell neurite elongation.
Gene Full Name: discoidin domain receptor tyrosine kinase 1
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基因ID
- 780
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UniProt
- Q08345
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途径
- RTK signaling, Smooth Muscle Cell Migration
抗原
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