CISH 抗体 (C-Term) (HRP)
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北京 101111
Quick Overview for CISH 抗体 (C-Term) (HRP) (ABIN7983536)
抗原
See all CISH 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Anti-CISH Antibody HRP Conjugated
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特异性
- No cross reactivity with other proteins.
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交叉反应 （详细）
- No cross-reactivity with other proteins
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预测反应
- identical to the related rat,mouse sequences.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human CISH, identical to the related rat and mouse sequences.
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亚型
- IgG
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anti-Cytokine Inducible SH2-Containing Protein (CISH) (C-Term) antibody
CISH 适用: 人 WB, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 1-258) antibodyCISH 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 1-258) antibodyCISH 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 79-256) antibodyCISH 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 1-258) antibodyCISH 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 1-257) antibodyCISH 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 17-130) antibodyCISH 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (C-Term) antibodyCISH 适用: 人, 小鼠, 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (Internal Region) antibodyCISH 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cytokine Inducible SH2-Containing Protein (CISH) (AA 78-127) antibodyCISH 适用: 人, 小鼠, 大鼠, Pig, Cow, 马, 犬, 兔, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
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有效期
- 12 months
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- CISH (Cytokine Inducible SH2-Containing Protein (CISH))
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别名
- CISH
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背景
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Background: CISH (cytokine inducible SH2-containing protein),also called CIS, CIS-1, G18, SOCS, is an important negative regulator for inflammatory signaling and belongs to the suppressors of cytokine signaling (SOCS) family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. CISH controls interleukin-2 signaling, and variations of CISH with certain SNPs are associated with susceptibility to bacteremia, tuberculosis and malaria. The human CISH gene is mapped to chromosome 3p21.3 by FISH. The mouse gene is tightly linked to the Gnai2 gene on chromosome 9, a region syntenic to human chromosome 3p21. CIS expression was upregulated by lipopolysaccharide (LPS) or Cryptosporidium parvum exposure, and this upregulation involved downregulation of MIR98 and LET7, which relieved MIR98- and LET7-mediated translational repression of CIS. Gain- and loss-of-function studies showed that CIS accelerated degradation of IKBA and enhanced NFKB activation in cholangiocytes in response to LPS stimulation or C parvum exposure.
Gene Full Name: cytokine inducible SH2 containing protein
Sequence Similarities: Contains 1 SH2 domain.
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基因ID
- 1154
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UniProt
- Q9NSE2
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途径
- JAK/STAT Signaling, Response to Growth Hormone Stimulus
抗原
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