CSK 抗体 (AA 2-204) (APC)
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北京 101111
Quick Overview for CSK 抗体 (AA 2-204) (APC) (ABIN7973671)
抗原
See all CSK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 2-204
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原理
- Anti-Csk Antibody APC Conjugated
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特异性
- No cross reactivity with other proteins.
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交叉反应 (详细)
- No cross-reactivity with other proteins
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预测反应
- Human CSK shares 99% amino acid (aa) sequence identity with both mouse,rat CSK.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human CSK recombinant protein (Position: S2-G204). Human CSK shares 99% amino acid (aa) sequence identity with both mouse and rat CSK.
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亚型
- IgG
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- CSK (C-Src tyrosine Kinase (CSK))
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别名
- CSK
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背景
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Background: CSK also known as C-Src kinase, is a non-receptor protein tyrosine kinase protein that in humans is encoded by the CSK gene. It is mapped to 15q24.1. CSK suppresses activity of the Src family of protein kinases by phosphorylation of Src family members at a conserved C-terminal site in Src. Csk's control of the Src family activity is widely thought to be central to regulation of the immune response. CSK can downregulate tyrosine kinase activity of the SRC oncoprotein through tyrosine phosphorylation of the SRC carboxy terminus. Since cell transformation by SRC oncoproteins is caused by various mechanisms that interfere with this phosphorylation, the CSK gene might function as an antioncogene.
Gene Full Name: C-terminal Src kinase
Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
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基因ID
- 1445
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UniProt
- P41240
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途径
- TCR Signaling, EGFR Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events
抗原
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